Manufacturing controls for the fabrication of tissue scaffolds with graded microstructures

D. Hoelzle, S. Svientek, A. Alleyne, A. Wagoner Johnson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

It is well known that mechanical properties are an important consideration for scaffold design in tissue engineering. Commonly scaffold stiffness and macroscale (200 μm to 1 mm) pore interconnection size are investigated for their influence on new tissue growth. Microscale (2 to 20 μm) porosity has received less attention, but recent in vivo studies highlight the sensitivity of bone ingrowth to scaffold microstructure. Currently there are not fabrication methods to vary microporosity within a single structure. This work provides a control method for solid freeform fabrication processes that enables precise material placement control and the ability to interchange materials. We demonstrate the control method with the fabrication of combinatorial samples; samples which test multiple micro- and macropore design options within a single structure. The ability to fabricate scaffolds with this design will lead to more efficient in vivo evaluation of the effect of porosity on scaffold viability.

Original languageEnglish (US)
Title of host publicationMaterials Science and Technology Conference and Exhibition 2011, MS and T'11
Pages1469-1476
Number of pages8
StatePublished - Dec 1 2011
EventMaterials Science and Technology Conference and Exhibition 2011, MS and T'11 - Columbus, OH, United States
Duration: Oct 16 2011Oct 20 2011

Publication series

NameMaterials Science and Technology Conference and Exhibition 2011, MS and T'11
Volume2

Other

OtherMaterials Science and Technology Conference and Exhibition 2011, MS and T'11
CountryUnited States
CityColumbus, OH
Period10/16/1110/20/11

Keywords

  • Ceramic forming technology
  • Manufacturing controls
  • Solid freeform manufacturing
  • Tissue engineering

ASJC Scopus subject areas

  • Materials Science(all)

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  • Cite this

    Hoelzle, D., Svientek, S., Alleyne, A., & Wagoner Johnson, A. (2011). Manufacturing controls for the fabrication of tissue scaffolds with graded microstructures. In Materials Science and Technology Conference and Exhibition 2011, MS and T'11 (pp. 1469-1476). (Materials Science and Technology Conference and Exhibition 2011, MS and T'11; Vol. 2).