Mammary Gland: Gene Networks Controlling Development and Involution

J. J. Loor, M. Bionaz, W. L. Hurley

Research output: Chapter in Book/Report/Conference proceedingChapter


Microarray technology is a powerful tool for the simultaneous analysis of the expression of thousands of genes in tissues, organs, or cells. DNA sequence information encoding RNA for specific genes is physically printed onto microarray 'chips', thus allowing measurement of the abundance of each RNA molecule in a biological sample. Through the use of bioinformatics, clustering, and gene network analysis, this technology is beginning to allow the identification of regulatory mechanisms that are associated with functional developments of the bovine mammary gland during late pregnancy, lactation, and involution, as well as prepubertal development. Use of genome-enabled technologies (microarrays, proteomics, gene silencing) will contribute to our understanding of regulatory points at each stage of mammary development and will provide new insights into, and opportunities for, enhancing mammary growth and efficiency of milk production.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Dairy Sciences
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages6
ISBN (Electronic)9780123744029
ISBN (Print)9780123744074
StatePublished - Jan 1 2011


  • Bioinformatics
  • Development
  • Fat Pad
  • Genomics
  • Involution
  • Lactation
  • Mammary gland
  • Parenchyma
  • Pregnancy

ASJC Scopus subject areas

  • General Engineering
  • General Agricultural and Biological Sciences


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