Mammalian target of rapamycin (mTOR) signaling network in skeletal myogenesis

Yejing Ge, Jie Chen

Research output: Contribution to journalShort survey

Abstract

Mammalian (or mechanistic) target of rapamycin (mTOR) regulates a wide range of cellular and developmental processes by coordinating signaling responses to mitogens, nutrients, and various stresses. Over the last decade, mTOR has emerged as a master regulator of skeletal myogenesis, controlling multiple stages of the myofiber formation process. In this minireview, we present an emerging view of the signaling network underlying mTOR regulation of myogenesis, which contrasts with the well established mechanisms in the regulation of cell and muscle growth. Current questions for future studies are also highlighted.

Original languageEnglish (US)
Pages (from-to)43928-43935
Number of pages8
JournalJournal of Biological Chemistry
Volume287
Issue number52
DOIs
StatePublished - Dec 21 2012

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Muscle Development
Sirolimus
Mitogens
Muscle Cells
Nutrients
Muscle
Cells
Food
Growth

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Mammalian target of rapamycin (mTOR) signaling network in skeletal myogenesis. / Ge, Yejing; Chen, Jie.

In: Journal of Biological Chemistry, Vol. 287, No. 52, 21.12.2012, p. 43928-43935.

Research output: Contribution to journalShort survey

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