Mammalian microRNAs derived from genomic repeats

Neil R. Smalheiser, Vetle Ingvald Torvik

Research output: Contribution to journalShort survey

Abstract

In this article, we show that a subset of conventional mammalian microRNAs is derived from LINE-2 transposable elements and other genome repeats. These repeat-derived microRNAs arise from conventional precursor hairpins and are distinct from the rasiRNAs, which appear to be processed from long double-stranded RNA precursors. The insertion of transposable elements into new genomic sites appears to be one of the driving-forces that create new microRNAs during mammalian evolution. Two of the LINE-2-derived microRNAs exhibit perfect complementarity to a large family of mRNA and EST transcripts that contain portions of MIR and other LINE-2 elements in their 3′-untranslated regions.

Original languageEnglish (US)
Pages (from-to)322-326
Number of pages5
JournalTrends in Genetics
Volume21
Issue number6
DOIs
StatePublished - Jun 2005
Externally publishedYes

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MicroRNAs
DNA Transposable Elements
Double-Stranded RNA
Expressed Sequence Tags
RNA Precursors
3' Untranslated Regions
Genome
Messenger RNA

ASJC Scopus subject areas

  • Genetics

Cite this

Mammalian microRNAs derived from genomic repeats. / Smalheiser, Neil R.; Torvik, Vetle Ingvald.

In: Trends in Genetics, Vol. 21, No. 6, 06.2005, p. 322-326.

Research output: Contribution to journalShort survey

Smalheiser, Neil R. ; Torvik, Vetle Ingvald. / Mammalian microRNAs derived from genomic repeats. In: Trends in Genetics. 2005 ; Vol. 21, No. 6. pp. 322-326.
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