Magnetomotive Optical Coherence Elastography for Magnetic Hyperthermia Dosimetry Based on Dynamic Tissue Biomechanics

Pin Chieh Huang, Paritosh Pande, Adeel Ahmad, Marina Marjanovic, Darold R. Spillman, Boris Odintsov, Stephen A. Boppart

Research output: Contribution to journalReview article

Abstract

Magnetic nanoparticles (MNPs) have been used in many diagnostic and therapeutic biomedical applications over the past few decades to enhance imaging contrast, steer drugs to targets, and treat tumors via hyperthermia. Optical coherence tomography (OCT) is an optical biomedical imaging modality that relies on the detection of backscattered light to generate high-resolution cross-sectional images of biological tissue. MNPs have been utilized as imaging contrast and perturbative mechanical agents in OCT in techniques called magnetomotive OCT (MM-OCT) and magnetomotive elastography (MM-OCE), respectively. MNPs have also been independently used for magnetic hyperthermia treatments, enabling therapeutic functions such as killing tumor cells. It is well known that the localized tissue heating during hyperthermia treatments result in a change in the biomechanical properties of the tissue. Therefore, we propose a novel dosimetric technique for hyperthermia treatment based on the viscoelasticity change detected by MM-OCE, further enabling the theranostic function of MNPs. In this paper, we first review the basic principles and applications of MM-OCT, MM-OCE, and magnetic hyperthermia, and present new preliminary results supporting the concept of MM-OCE-based hyperthermia dosimetry.

Original languageEnglish (US)
Article number7355327
JournalIEEE Journal of Selected Topics in Quantum Electronics
Volume22
Issue number4
DOIs
StatePublished - Jul 1 2016

Fingerprint

biodynamics
Biomechanics
hyperthermia
Dosimetry
dosimeters
Optical tomography
Tissue
Nanoparticles
Imaging techniques
Tumors
nanoparticles
tomography
Viscoelasticity
tumors
viscoelasticity
Cells
Heating
drugs
heating
high resolution

Keywords

  • Magnetomotive nanoparticles
  • biomechanics
  • magnetic hyperthermia
  • optical coherence elastography
  • optical coherence tomography
  • theranostic
  • thermotherapy

ASJC Scopus subject areas

  • Ceramics and Composites
  • Atomic and Molecular Physics, and Optics
  • Materials Chemistry
  • Electrical and Electronic Engineering

Cite this

Magnetomotive Optical Coherence Elastography for Magnetic Hyperthermia Dosimetry Based on Dynamic Tissue Biomechanics. / Huang, Pin Chieh; Pande, Paritosh; Ahmad, Adeel; Marjanovic, Marina; Spillman, Darold R.; Odintsov, Boris; Boppart, Stephen A.

In: IEEE Journal of Selected Topics in Quantum Electronics, Vol. 22, No. 4, 7355327, 01.07.2016.

Research output: Contribution to journalReview article

Huang, Pin Chieh ; Pande, Paritosh ; Ahmad, Adeel ; Marjanovic, Marina ; Spillman, Darold R. ; Odintsov, Boris ; Boppart, Stephen A. / Magnetomotive Optical Coherence Elastography for Magnetic Hyperthermia Dosimetry Based on Dynamic Tissue Biomechanics. In: IEEE Journal of Selected Topics in Quantum Electronics. 2016 ; Vol. 22, No. 4.
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