Magnetomotive contrast in optical coherence tomography for detecting early-stage atherosclerosis using targeted microspheres

Adeel Ahmad, Jong S. Kim, Joanne Li, Jonathan Rasio, Zita Hubler, Eric J. Chaney, Marina Marjanovic, Kenneth S Suslick, Stephen A. Boppart

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this work, we show that molecularly-sensitive contrast can be generated in OCT using targeted multifunctional magnetic microspheres. These microspheres were engineered to target the ΑvΒ3 integrin for the localization of atherosclerotic lesions in excised aortas from a rabbit animal model. The aortas were extracted and placed in a flow chamber, which mimicked the physiological blood flow conditions in the living rabbit. Magnetic microspheres were perfused through the aorta inside the flow chamber and catheter-based OCT imaging, magnetomotive optical coherence tomography (MM-OCT), fluorescence confocal, and bright field microscopy was performed on the ex vivo aorta specimens for localizing the microspheres. Results showed successful targeting of the functionalized microspheres to early atherosclerotic lesions, and good co-registration of MM-OCT signal with confocal microscopy.

Original languageEnglish (US)
Title of host publicationBiomedical Optics, BIOMED 2012
PagesBTu3A.85
StatePublished - Dec 1 2012
EventBiomedical Optics, BIOMED 2012 - Miami, FL, United States
Duration: Apr 28 2012May 2 2012

Publication series

NameBiomedical Optics, BIOMED 2012

Other

OtherBiomedical Optics, BIOMED 2012
CountryUnited States
CityMiami, FL
Period4/28/125/2/12

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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    Ahmad, A., Kim, J. S., Li, J., Rasio, J., Hubler, Z., Chaney, E. J., Marjanovic, M., Suslick, K. S., & Boppart, S. A. (2012). Magnetomotive contrast in optical coherence tomography for detecting early-stage atherosclerosis using targeted microspheres. In Biomedical Optics, BIOMED 2012 (pp. BTu3A.85). (Biomedical Optics, BIOMED 2012).