Abstract

Molecularly-specific contrast can greatly enhance the biomedical utility of optical coherence tomography (OCT). We describe a contrast mechanism, magnetomotive OCT (MMOCT), where a modulated magnetic field induces motion of magnetic nanoparticles. The motion of the nanoparticles modifies the amplitude of the OCT interferogram. High specificity is achieved by subtracting the background fluctuations of the specimen, and sensitivity to 220 μg/g magnetite nanoparticles is demonstrated. Optically and mechanically correct tissue phantoms elucidate the relationships between imaging contrast and nanoparticle concentration, imaging depth, tissue optical scattering, and magnetic field strength. MMOCT is demonstrated in a living Xenopus laevis tadpole where the results were consistent with corresponding histology.

Original languageEnglish (US)
Pages (from-to)6597-6614
Number of pages18
JournalOptics Express
Volume13
Issue number17
DOIs
StatePublished - Aug 22 2005

Fingerprint

tomography
nanoparticles
histology
magnetic fields
magnetite
field strength
interferometry
sensitivity
scattering

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Magnetomotive contrast for in vivo optical coherence tomography. / Oldenburg, Amy L.; Toublan, Farah Jean Jacques; Suslick, Kenneth S; Wei, Alexander; Boppart, Stephen A.

In: Optics Express, Vol. 13, No. 17, 22.08.2005, p. 6597-6614.

Research output: Contribution to journalReview article

Oldenburg, Amy L. ; Toublan, Farah Jean Jacques ; Suslick, Kenneth S ; Wei, Alexander ; Boppart, Stephen A. / Magnetomotive contrast for in vivo optical coherence tomography. In: Optics Express. 2005 ; Vol. 13, No. 17. pp. 6597-6614.
@article{71a63ef91d054a8b94fac0a3c96193f3,
title = "Magnetomotive contrast for in vivo optical coherence tomography",
abstract = "Molecularly-specific contrast can greatly enhance the biomedical utility of optical coherence tomography (OCT). We describe a contrast mechanism, magnetomotive OCT (MMOCT), where a modulated magnetic field induces motion of magnetic nanoparticles. The motion of the nanoparticles modifies the amplitude of the OCT interferogram. High specificity is achieved by subtracting the background fluctuations of the specimen, and sensitivity to 220 μg/g magnetite nanoparticles is demonstrated. Optically and mechanically correct tissue phantoms elucidate the relationships between imaging contrast and nanoparticle concentration, imaging depth, tissue optical scattering, and magnetic field strength. MMOCT is demonstrated in a living Xenopus laevis tadpole where the results were consistent with corresponding histology.",
author = "Oldenburg, {Amy L.} and Toublan, {Farah Jean Jacques} and Suslick, {Kenneth S} and Alexander Wei and Boppart, {Stephen A.}",
year = "2005",
month = "8",
day = "22",
doi = "10.1364/OPEX.13.006597",
language = "English (US)",
volume = "13",
pages = "6597--6614",
journal = "Optics Express",
issn = "1094-4087",
publisher = "The Optical Society",
number = "17",

}

TY - JOUR

T1 - Magnetomotive contrast for in vivo optical coherence tomography

AU - Oldenburg, Amy L.

AU - Toublan, Farah Jean Jacques

AU - Suslick, Kenneth S

AU - Wei, Alexander

AU - Boppart, Stephen A.

PY - 2005/8/22

Y1 - 2005/8/22

N2 - Molecularly-specific contrast can greatly enhance the biomedical utility of optical coherence tomography (OCT). We describe a contrast mechanism, magnetomotive OCT (MMOCT), where a modulated magnetic field induces motion of magnetic nanoparticles. The motion of the nanoparticles modifies the amplitude of the OCT interferogram. High specificity is achieved by subtracting the background fluctuations of the specimen, and sensitivity to 220 μg/g magnetite nanoparticles is demonstrated. Optically and mechanically correct tissue phantoms elucidate the relationships between imaging contrast and nanoparticle concentration, imaging depth, tissue optical scattering, and magnetic field strength. MMOCT is demonstrated in a living Xenopus laevis tadpole where the results were consistent with corresponding histology.

AB - Molecularly-specific contrast can greatly enhance the biomedical utility of optical coherence tomography (OCT). We describe a contrast mechanism, magnetomotive OCT (MMOCT), where a modulated magnetic field induces motion of magnetic nanoparticles. The motion of the nanoparticles modifies the amplitude of the OCT interferogram. High specificity is achieved by subtracting the background fluctuations of the specimen, and sensitivity to 220 μg/g magnetite nanoparticles is demonstrated. Optically and mechanically correct tissue phantoms elucidate the relationships between imaging contrast and nanoparticle concentration, imaging depth, tissue optical scattering, and magnetic field strength. MMOCT is demonstrated in a living Xenopus laevis tadpole where the results were consistent with corresponding histology.

UR - http://www.scopus.com/inward/record.url?scp=24144492996&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24144492996&partnerID=8YFLogxK

U2 - 10.1364/OPEX.13.006597

DO - 10.1364/OPEX.13.006597

M3 - Review article

C2 - 19498675

AN - SCOPUS:24144492996

VL - 13

SP - 6597

EP - 6614

JO - Optics Express

JF - Optics Express

SN - 1094-4087

IS - 17

ER -