Magneto-photo-acoustic imaging

Min Qu, Srivalleesha Mallidi, Mohammad Mehrmohammadi, Ryan Truby, Kimberly Homan, Pratixa Joshi, Yun Sheng Chen, Konstantin Sokolov, Stanislav Emelianov

Research output: Contribution to journalArticle

Abstract

Magneto-photo-acoustic imaging, a technique based on the synergy of magneto-motive ultrasound, photoacoustic and ultrasound imaging, is introduced. Hybrid nanoconstructs, liposomes encapsulating gold nanorods and iron oxide nanoparticles, were used as a dual-contrast agent for magneto-photo-acoustic imaging. Tissue-mimicking phantom and macrophage cells embedded in ex vivo porcine tissue were used to demonstrate that magneto-photo-acoustic imaging is capable of visualizing the location of cells or tissues labeled with dual-contrast nanoparticles with sufficient contrast, excellent contrast resolution and high spatial resolution in the context of the anatomical structure of the surrounding tissues. Therefore, magneto-photo-acoustic imaging is capable of identifying the nanoparticle-labeled pathological regions from the normal tissue, providing a promising platform to noninvasively diagnose and characterize pathologies.

Original languageEnglish (US)
Pages (from-to)385-396
Number of pages12
JournalBiomedical Optics Express
Volume2
Issue number2
DOIs
StatePublished - Feb 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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  • Cite this

    Qu, M., Mallidi, S., Mehrmohammadi, M., Truby, R., Homan, K., Joshi, P., Chen, Y. S., Sokolov, K., & Emelianov, S. (2011). Magneto-photo-acoustic imaging. Biomedical Optics Express, 2(2), 385-396. https://doi.org/10.1364/BOE.2.000385