Magnetic targeting of human aortic smooth muscle cells for rapid closure and healing of intracranial aneurysm/pseudoaneurysm

S. L. Arias, M. Alucozai, F. Pastrana, L. M. Reece, R. Kempaiah, J. J. Pavon, J. P. Allain

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The aneurysm/pseudoaneurysm treatment requires a complete and definitive occlusion of the deffect from the parental artery to prevent bleeding. Current approaches such as coil embolization are still suboptimal for aneurysm sac occlusion, exhibiting various documented postsurgery recurrences. Asymetric bioactive stents with a magnetic surface able to attract magnetized cells may promote a rapid aneurysm treatment by bringing the aneurysm neck. An efficient cell internalization of nanoparticles is a perrequisite to address the feasiability of these approaches. In this study, cell magnetization using low pulse and low voltage electroporation parameters are assessed, and their effects on cell viability, genotoxicity, and nanoparticle internalization are shown.

Original languageEnglish (US)
Title of host publicationTechnical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
Pages373-376
Number of pages4
Volume3
StatePublished - 2013
Externally publishedYes
EventNanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 - Washington, DC, United States

Other

OtherNanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
CountryUnited States
CityWashington, DC
Period5/12/135/16/13

Fingerprint

False Aneurysm
Intracranial Aneurysm
Aneurysm
Nanoparticles
Electroporation
Stents
Cell Survival
Arteries
Hemorrhage
Recurrence

Keywords

  • Aneurysm treatment
  • Electroporation
  • Iron oxide nanoparticles
  • Magnetic targeting
  • Vascular healing

ASJC Scopus subject areas

  • Biotechnology

Cite this

Arias, S. L., Alucozai, M., Pastrana, F., Reece, L. M., Kempaiah, R., Pavon, J. J., & Allain, J. P. (2013). Magnetic targeting of human aortic smooth muscle cells for rapid closure and healing of intracranial aneurysm/pseudoaneurysm. In Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 (Vol. 3, pp. 373-376)

Magnetic targeting of human aortic smooth muscle cells for rapid closure and healing of intracranial aneurysm/pseudoaneurysm. / Arias, S. L.; Alucozai, M.; Pastrana, F.; Reece, L. M.; Kempaiah, R.; Pavon, J. J.; Allain, J. P.

Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013. Vol. 3 2013. p. 373-376.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Arias, SL, Alucozai, M, Pastrana, F, Reece, LM, Kempaiah, R, Pavon, JJ & Allain, JP 2013, Magnetic targeting of human aortic smooth muscle cells for rapid closure and healing of intracranial aneurysm/pseudoaneurysm. in Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013. vol. 3, pp. 373-376, Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013, Washington, DC, United States, 12-16 May.
Arias SL, Alucozai M, Pastrana F, Reece LM, Kempaiah R, Pavon JJ et al. Magnetic targeting of human aortic smooth muscle cells for rapid closure and healing of intracranial aneurysm/pseudoaneurysm. In Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013. Vol. 3. 2013. p. 373-376.

Arias, S. L.; Alucozai, M.; Pastrana, F.; Reece, L. M.; Kempaiah, R.; Pavon, J. J.; Allain, J. P. / Magnetic targeting of human aortic smooth muscle cells for rapid closure and healing of intracranial aneurysm/pseudoaneurysm.

Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013. Vol. 3 2013. p. 373-376.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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