Magnetic gradiometer based on a high-transition temperature superconducting quantum interference device for improved sensitivity of a biosensor

Seungkyun Lee, W. R. Myers, H. L. Grossman, H. M. Cho, Y. R. Chemla, John Clarke

Research output: Contribution to journalArticle

Abstract

We describe a gradiometer based on a high-transition temperature superconducting quantum interference device (SQUID) that improves the sensitivity of a SQUID-based biosensor. The first-derivative gradiometer, fabricated from a single layer of YBa2Cu3O7-x, has a baseline of 480 μm and a balance against uniform fields of 1 part in 150. Used in our SQUID "microscope," it reduces the response to parasitic magnetic fields generated by the measurement process to the level of the SQUID noise. The gradiometer-based microscope is two orders of magnitude more sensitive to superparamagnetic nanoparticles bound to biological targets than our earlier magnetometer-based microscope.

Original languageEnglish (US)
Pages (from-to)3094-3096
Number of pages3
JournalApplied Physics Letters
Volume81
Issue number16
DOIs
StatePublished - Oct 14 2002
Externally publishedYes

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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