Macular Xanthophylls and Event-Related Brain Potentials among Overweight Adults and Those with Obesity

Caitlyn G. Edwards, Anne M. Walk, Corinne N. Cannavale, Sharon V. Thompson, Ginger E. Reeser, Hannah D. Holscher, Naiman A. Khan

Research output: Contribution to journalArticle

Abstract

Scope: Macular accumulation of xanthophyll carotenoids (lutein, zeaxanthin) is known to have neuroprotective potential, yet their influence on cognition among overweight adults and those with obesity remains limited. This study examines the impact of macular xanthophylls on attentional resource allocation and information processing speed among adults with BMI ≥ 25 kg m−2. Methods and Results: Adults between 25 and 45 years (N = 101) complete heterochromatic flicker photometry to determine macular pigment optical density (MPOD). Event-related brain potentials are recorded during a visual oddball task. Amplitude and latency of the N2 and P3 indexed attentional resource allocation and information processing speed. Covariates included age, sex, education, intelligence quotient (IQ), %Fat (DXA), and dietary lutein and zeaxanthin (Diet History Questionnaire II). MPOD is inversely related to P3 peak amplitude during standard trials and P3 peak latency during target trials. Therefore, individuals with higher MPOD dedicate fewer attentional resources when attentional demands are low while exhibiting faster information processing speed when attentional demands are increased. Further, MPOD is inversely related to the N2 mean amplitude during targets, signifying greater inhibitory control. Conclusion: These findings are the first to link macular xanthophylls to neuroelectric indices of attentional and inhibitory control among adults with overweight and obesity.

Original languageEnglish (US)
Article number1801059
JournalMolecular Nutrition and Food Research
Volume63
Issue number15
DOIs
StatePublished - Jan 1 2019

Fingerprint

Xanthophylls
xanthophylls
Evoked Potentials
absorbance
obesity
Obesity
lutein
Automatic Data Processing
pigments
brain
Lutein
Resource Allocation
Brain
zeaxanthin
resource allocation
Photometry
diet history
Sex Education
Dietary Fats
Intelligence

Keywords

  • body composition
  • carotenoids
  • diet
  • executive function
  • neuroefficiency

ASJC Scopus subject areas

  • Biotechnology
  • Food Science

Cite this

Macular Xanthophylls and Event-Related Brain Potentials among Overweight Adults and Those with Obesity. / Edwards, Caitlyn G.; Walk, Anne M.; Cannavale, Corinne N.; Thompson, Sharon V.; Reeser, Ginger E.; Holscher, Hannah D.; Khan, Naiman A.

In: Molecular Nutrition and Food Research, Vol. 63, No. 15, 1801059, 01.01.2019.

Research output: Contribution to journalArticle

Edwards, Caitlyn G. ; Walk, Anne M. ; Cannavale, Corinne N. ; Thompson, Sharon V. ; Reeser, Ginger E. ; Holscher, Hannah D. ; Khan, Naiman A. / Macular Xanthophylls and Event-Related Brain Potentials among Overweight Adults and Those with Obesity. In: Molecular Nutrition and Food Research. 2019 ; Vol. 63, No. 15.
@article{2aee57c3d72248049db8f468481a0a64,
title = "Macular Xanthophylls and Event-Related Brain Potentials among Overweight Adults and Those with Obesity",
abstract = "Scope: Macular accumulation of xanthophyll carotenoids (lutein, zeaxanthin) is known to have neuroprotective potential, yet their influence on cognition among overweight adults and those with obesity remains limited. This study examines the impact of macular xanthophylls on attentional resource allocation and information processing speed among adults with BMI ≥ 25 kg m−2. Methods and Results: Adults between 25 and 45 years (N = 101) complete heterochromatic flicker photometry to determine macular pigment optical density (MPOD). Event-related brain potentials are recorded during a visual oddball task. Amplitude and latency of the N2 and P3 indexed attentional resource allocation and information processing speed. Covariates included age, sex, education, intelligence quotient (IQ), {\%}Fat (DXA), and dietary lutein and zeaxanthin (Diet History Questionnaire II). MPOD is inversely related to P3 peak amplitude during standard trials and P3 peak latency during target trials. Therefore, individuals with higher MPOD dedicate fewer attentional resources when attentional demands are low while exhibiting faster information processing speed when attentional demands are increased. Further, MPOD is inversely related to the N2 mean amplitude during targets, signifying greater inhibitory control. Conclusion: These findings are the first to link macular xanthophylls to neuroelectric indices of attentional and inhibitory control among adults with overweight and obesity.",
keywords = "body composition, carotenoids, diet, executive function, neuroefficiency",
author = "Edwards, {Caitlyn G.} and Walk, {Anne M.} and Cannavale, {Corinne N.} and Thompson, {Sharon V.} and Reeser, {Ginger E.} and Holscher, {Hannah D.} and Khan, {Naiman A.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/mnfr.201801059",
language = "English (US)",
volume = "63",
journal = "Molecular Nutrition and Food Research",
issn = "1613-4125",
publisher = "Wiley-VCH Verlag",
number = "15",

}

TY - JOUR

T1 - Macular Xanthophylls and Event-Related Brain Potentials among Overweight Adults and Those with Obesity

AU - Edwards, Caitlyn G.

AU - Walk, Anne M.

AU - Cannavale, Corinne N.

AU - Thompson, Sharon V.

AU - Reeser, Ginger E.

AU - Holscher, Hannah D.

AU - Khan, Naiman A.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Scope: Macular accumulation of xanthophyll carotenoids (lutein, zeaxanthin) is known to have neuroprotective potential, yet their influence on cognition among overweight adults and those with obesity remains limited. This study examines the impact of macular xanthophylls on attentional resource allocation and information processing speed among adults with BMI ≥ 25 kg m−2. Methods and Results: Adults between 25 and 45 years (N = 101) complete heterochromatic flicker photometry to determine macular pigment optical density (MPOD). Event-related brain potentials are recorded during a visual oddball task. Amplitude and latency of the N2 and P3 indexed attentional resource allocation and information processing speed. Covariates included age, sex, education, intelligence quotient (IQ), %Fat (DXA), and dietary lutein and zeaxanthin (Diet History Questionnaire II). MPOD is inversely related to P3 peak amplitude during standard trials and P3 peak latency during target trials. Therefore, individuals with higher MPOD dedicate fewer attentional resources when attentional demands are low while exhibiting faster information processing speed when attentional demands are increased. Further, MPOD is inversely related to the N2 mean amplitude during targets, signifying greater inhibitory control. Conclusion: These findings are the first to link macular xanthophylls to neuroelectric indices of attentional and inhibitory control among adults with overweight and obesity.

AB - Scope: Macular accumulation of xanthophyll carotenoids (lutein, zeaxanthin) is known to have neuroprotective potential, yet their influence on cognition among overweight adults and those with obesity remains limited. This study examines the impact of macular xanthophylls on attentional resource allocation and information processing speed among adults with BMI ≥ 25 kg m−2. Methods and Results: Adults between 25 and 45 years (N = 101) complete heterochromatic flicker photometry to determine macular pigment optical density (MPOD). Event-related brain potentials are recorded during a visual oddball task. Amplitude and latency of the N2 and P3 indexed attentional resource allocation and information processing speed. Covariates included age, sex, education, intelligence quotient (IQ), %Fat (DXA), and dietary lutein and zeaxanthin (Diet History Questionnaire II). MPOD is inversely related to P3 peak amplitude during standard trials and P3 peak latency during target trials. Therefore, individuals with higher MPOD dedicate fewer attentional resources when attentional demands are low while exhibiting faster information processing speed when attentional demands are increased. Further, MPOD is inversely related to the N2 mean amplitude during targets, signifying greater inhibitory control. Conclusion: These findings are the first to link macular xanthophylls to neuroelectric indices of attentional and inhibitory control among adults with overweight and obesity.

KW - body composition

KW - carotenoids

KW - diet

KW - executive function

KW - neuroefficiency

UR - http://www.scopus.com/inward/record.url?scp=85070218189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070218189&partnerID=8YFLogxK

U2 - 10.1002/mnfr.201801059

DO - 10.1002/mnfr.201801059

M3 - Article

C2 - 30816627

AN - SCOPUS:85070218189

VL - 63

JO - Molecular Nutrition and Food Research

JF - Molecular Nutrition and Food Research

SN - 1613-4125

IS - 15

M1 - 1801059

ER -