Macular Carotenoids, Aerobic Fitness, and Central Adiposity Are Associated Differentially with Hippocampal-Dependent Relational Memory in Preadolescent Children

Kelsey M. Hassevoort, Sarah E. Khazoum, John A. Walker, Sasha M. Barnett, Lauren B. Raine, Billy R. Hammond, Lisa M. Renzi-Hammond, Arthur F. Kramer, Naiman A. Khan, Charles H. Hillman, Neal J. Cohen

Research output: Contribution to journalArticle

Abstract

Objectives To examine the associations of macular pigment carotenoids (lutein, meso-zeaxanthin, and zeaxanthin), aerobic fitness, and central adiposity with hippocampal-dependent relational memory in prepubescent children. Study design Children between 7 and 10 years of age (n = 40) completed a task designed to assess relational memory performance and participated in aerobic fitness, adiposity, and macular pigment optical density (MPOD) assessment. Aerobic fitness was assessed via a modified Balke treadmill protocol designed to measure maximal oxygen volume. Central adiposity was assessed via dual-energy x-ray absorptiometry. MPOD was measured psychophysically by the use of customized heterochromatic flicker photometry. Statistical analyses included correlations and hierarchical linear regression. Results Aerobic fitness and MPOD were associated negatively with relational memory errors (P < .01), whereas central adiposity was associated positively with relational memory errors (P < .05). Hierarchical regression analysis revealed that MPOD accounted for a significant amount of the variance in relational memory performance even after we accounted for aerobic fitness (β = −0.388, P = .007). Conclusions Even after we adjusted for aerobic fitness and central adiposity, factors known to relate to hippocampal-dependent memory, MPOD positively and significantly predicted hippocampal-dependent memory performance. Trial registration ClinicalTrials.gov: NCT01619826.

Original languageEnglish (US)
Pages (from-to)108-114.e1
JournalJournal of Pediatrics
Volume183
DOIs
StatePublished - Apr 1 2017

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Adiposity
Carotenoids
Photometry
Lutein
Macular Pigment
Linear Models
Regression Analysis
X-Rays
Oxygen

Keywords

  • MPOD
  • childhood
  • development
  • health factors
  • swap error

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Macular Carotenoids, Aerobic Fitness, and Central Adiposity Are Associated Differentially with Hippocampal-Dependent Relational Memory in Preadolescent Children. / Hassevoort, Kelsey M.; Khazoum, Sarah E.; Walker, John A.; Barnett, Sasha M.; Raine, Lauren B.; Hammond, Billy R.; Renzi-Hammond, Lisa M.; Kramer, Arthur F.; Khan, Naiman A.; Hillman, Charles H.; Cohen, Neal J.

In: Journal of Pediatrics, Vol. 183, 01.04.2017, p. 108-114.e1.

Research output: Contribution to journalArticle

Hassevoort, Kelsey M. ; Khazoum, Sarah E. ; Walker, John A. ; Barnett, Sasha M. ; Raine, Lauren B. ; Hammond, Billy R. ; Renzi-Hammond, Lisa M. ; Kramer, Arthur F. ; Khan, Naiman A. ; Hillman, Charles H. ; Cohen, Neal J. / Macular Carotenoids, Aerobic Fitness, and Central Adiposity Are Associated Differentially with Hippocampal-Dependent Relational Memory in Preadolescent Children. In: Journal of Pediatrics. 2017 ; Vol. 183. pp. 108-114.e1.
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abstract = "Objectives To examine the associations of macular pigment carotenoids (lutein, meso-zeaxanthin, and zeaxanthin), aerobic fitness, and central adiposity with hippocampal-dependent relational memory in prepubescent children. Study design Children between 7 and 10 years of age (n = 40) completed a task designed to assess relational memory performance and participated in aerobic fitness, adiposity, and macular pigment optical density (MPOD) assessment. Aerobic fitness was assessed via a modified Balke treadmill protocol designed to measure maximal oxygen volume. Central adiposity was assessed via dual-energy x-ray absorptiometry. MPOD was measured psychophysically by the use of customized heterochromatic flicker photometry. Statistical analyses included correlations and hierarchical linear regression. Results Aerobic fitness and MPOD were associated negatively with relational memory errors (P < .01), whereas central adiposity was associated positively with relational memory errors (P < .05). Hierarchical regression analysis revealed that MPOD accounted for a significant amount of the variance in relational memory performance even after we accounted for aerobic fitness (β = −0.388, P = .007). Conclusions Even after we adjusted for aerobic fitness and central adiposity, factors known to relate to hippocampal-dependent memory, MPOD positively and significantly predicted hippocampal-dependent memory performance. Trial registration ClinicalTrials.gov: NCT01619826.",
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AU - Khazoum, Sarah E.

AU - Walker, John A.

AU - Barnett, Sasha M.

AU - Raine, Lauren B.

AU - Hammond, Billy R.

AU - Renzi-Hammond, Lisa M.

AU - Kramer, Arthur F.

AU - Khan, Naiman A.

AU - Hillman, Charles H.

AU - Cohen, Neal J.

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AB - Objectives To examine the associations of macular pigment carotenoids (lutein, meso-zeaxanthin, and zeaxanthin), aerobic fitness, and central adiposity with hippocampal-dependent relational memory in prepubescent children. Study design Children between 7 and 10 years of age (n = 40) completed a task designed to assess relational memory performance and participated in aerobic fitness, adiposity, and macular pigment optical density (MPOD) assessment. Aerobic fitness was assessed via a modified Balke treadmill protocol designed to measure maximal oxygen volume. Central adiposity was assessed via dual-energy x-ray absorptiometry. MPOD was measured psychophysically by the use of customized heterochromatic flicker photometry. Statistical analyses included correlations and hierarchical linear regression. Results Aerobic fitness and MPOD were associated negatively with relational memory errors (P < .01), whereas central adiposity was associated positively with relational memory errors (P < .05). Hierarchical regression analysis revealed that MPOD accounted for a significant amount of the variance in relational memory performance even after we accounted for aerobic fitness (β = −0.388, P = .007). Conclusions Even after we adjusted for aerobic fitness and central adiposity, factors known to relate to hippocampal-dependent memory, MPOD positively and significantly predicted hippocampal-dependent memory performance. Trial registration ClinicalTrials.gov: NCT01619826.

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