Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy

Yu Zhang, Kaimin Cai, Chao Li, Qin Guo, Qinjun Chen, Xi He, Lisha Liu, Yujie Zhang, Yifei Lu, Xinli Chen, Tao Sun, Yongzhuo Huang, Jianjun Cheng, Chen Jiang

Research output: Contribution to journalArticle

Abstract

Various delivery vectors have been integrated within biologically derived membrane systems to extend their residential time and reduce their reticuloendothelial system (RES) clearance during systemic circulation. However, rational design is still needed to further improve the in situ penetration efficiency of chemo-drug-loaded membrane delivery-system formulations and their release profiles at the tumor site. Here, a macrophage-membrane-coated nanoparticle is developed for tumor-targeted chemotherapy delivery with a controlled release profile in response to tumor microenvironment stimuli. Upon fulfilling its mission of tumor homing and RES evasion, the macrophage-membrane coating can be shed via morphological changes driven by extracellular microenvironment stimuli. The nanoparticles discharged from the outer membrane coating show penetration efficiency enhanced by their size advantage and surface modifications. After internalization by the tumor cells, the loaded drug is quickly released from the nanoparticles in response to the endosome pH. The designed macrophage-membrane-coated nanoparticle (cskc-PPiP/PTX@Ma) exhibits an enhanced therapeutic effect inherited from both membrane-derived tumor homing and step-by-step controlled drug release. Thus, the combination of a biomimetic cell membrane and a cascade-responsive polymeric nanoparticle embodies an effective drug delivery system tailored to the tumor microenvironment.

Original languageEnglish (US)
Pages (from-to)1908-1915
Number of pages8
JournalNano letters
Volume18
Issue number3
DOIs
StatePublished - Mar 14 2018

Keywords

  • biomimetic delivery system
  • breast-cancer targeting
  • cascade-responsiveness
  • macrophage-membrane coating
  • tumor microenvironment

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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  • Cite this

    Zhang, Y., Cai, K., Li, C., Guo, Q., Chen, Q., He, X., Liu, L., Zhang, Y., Lu, Y., Chen, X., Sun, T., Huang, Y., Cheng, J., & Jiang, C. (2018). Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy. Nano letters, 18(3), 1908-1915. https://doi.org/10.1021/acs.nanolett.7b05263