TY - JOUR
T1 - Macromolecules with programmable shape, size, and chemistry
AU - Walsh, Dylan J.
AU - Guironnet, Damien
N1 - ACKNOWLEDGMENTS. PolyAnalytik Inc. is acknowledged for performing triple-detection GPC. AFM was carried out at Frederick Seitz Materials Research Laboratory Central Research Facilities, University of Illinois. Major funding for the 500-MHz Bruker CryoProbe was provided by the Roy J. Carver Charitable Trust to the School of Chemical Sciences NMR Laboratory. We acknowledge NSF Grant DMR-1727605. We thank Umicore for the generous gift of Grubbs catalysts.
PolyAnalytik Inc. is acknowledged for performing triple-detection GPC. AFM was carried out at Frederick Seitz Materials Research Laboratory Central Research Facilities, University of Illinois. Major funding for the 500-MHz Bruker CryoProbe was provided by the Roy J. Carver Charitable Trust to the School of Chemical Sciences NMR Laboratory. We acknowledge NSF Grant DMR-1727605. We thank Umicore for the generous gift of Grubbs catalysts.
PY - 2019/1/29
Y1 - 2019/1/29
N2 - Shape, size, and composition are the most fundamental design features, enabling highly complex functionalities. Despite recent advances, the independent control of shape, size, and chemistry of macromolecules remains a synthetic challenge. We report a scalable methodology to produce large, well-defined macromolecules with programmable shape, size, and chemistry that combines reactor engineering principles and controlled polymerizations. Specifically, bottlebrush polymers with conical, ellipsoidal, and concave architectures are synthesized using two orthogonal polymerizations. The chemical versatility is highlighted by the synthesis of a compositional asymmetric cone. The strong agreement between predictions and experiments validates the precision that this methodology offers.
AB - Shape, size, and composition are the most fundamental design features, enabling highly complex functionalities. Despite recent advances, the independent control of shape, size, and chemistry of macromolecules remains a synthetic challenge. We report a scalable methodology to produce large, well-defined macromolecules with programmable shape, size, and chemistry that combines reactor engineering principles and controlled polymerizations. Specifically, bottlebrush polymers with conical, ellipsoidal, and concave architectures are synthesized using two orthogonal polymerizations. The chemical versatility is highlighted by the synthesis of a compositional asymmetric cone. The strong agreement between predictions and experiments validates the precision that this methodology offers.
KW - Bottlebrush polymers
KW - Polymer nanostructure
KW - Reactor engineering
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U2 - 10.1073/pnas.1817745116
DO - 10.1073/pnas.1817745116
M3 - Article
C2 - 30655343
AN - SCOPUS:85060830287
SN - 0027-8424
VL - 116
SP - 1538
EP - 1542
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 5
ER -