Ménétrier's disease-like hypertrophic gastritis in two red-capped mangabeys (Cercocebus torquatus)

Jessica A. Emerson, Michael J. Adkesson, Kathleen M. Colegrove, Stacy K. Burdick, Jennifer N. Langan

Research output: Contribution to journalArticlepeer-review


Chronic lymphoplasmacytic gastritis in two red-capped mangabeys (Cercocebus torquatus) at a zoological facility progressed to severe hypertrophic gastropathy similar to Ménétrier's disease that affects humans. Clinical signs included emesis, diarrhea, hunched posture consistent with abdominal pain, anemia, and hypoproteinemia. Large gastric masses were present and in one case created a gastric outflow obstruction. Both cases were positive for simian immunodeficiency virus and Helicobacter spp. were variably isolated, although the association with the hypertrophic gastropathy is unclear. Medical treatment had varying success and included sucralfate, H2 receptor antagonists, proton pump inhibitors, diet manipulations, and antibiotic therapies targeting Helicobacter spp. Surgical resection of a large portion of the stomach resulted in some palliative improvement in one case. Overall, this disease presented many challenges regarding identification, confirmation of diagnosis, and clinical management. Both aggressive medical and surgical treatments were unrewarding for long-term management of hypertrophic gastropathy in this pair of red-capped mangabeys and resulted in a poor prognosis in these cases.

Original languageEnglish (US)
Pages (from-to)29-36
Number of pages8
JournalVeterinary Quarterly
Issue number1
StatePublished - Jan 2014


  • Cercocebus torquatus
  • Helicobacter spp.
  • Ménétrier's disease
  • gastric hypertrophy
  • gastritis
  • nonhuman primate
  • red-capped mangabeys

ASJC Scopus subject areas

  • General Veterinary


Dive into the research topics of 'Ménétrier's disease-like hypertrophic gastritis in two red-capped mangabeys (Cercocebus torquatus)'. Together they form a unique fingerprint.

Cite this