Luminescent quantum dots for multiplexed biological detection and imaging

Warren C.W. Chan, Dustin J. Maxwell, Xiaohu Gao, Robert E. Bailey, Mingyong Han, Shuming Nie

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent advances in nanomaterials have produced a new class of fluorescent labels by conjugating semiconductor quantum dots with biorecognition molecules. These nanometer-sized conjugates are water-soluble and biocompatible, and provide important advantages over organic dyes and lanthanide probes. In particular, the emission wavelength of quantum-dot nanocrystals can be continuously tuned by changing the particle size, and a single light source can be used for simultaneous excitation of all different-sized dots. High-quality dots are also highly stable against photobleaching and have narrow, symmetric emission spectra. These novel optical properties render quantum dots ideal fluorophores for ultrasensitive, multicolor, and multiplexing applications in molecular biotechnology and bioengineering.

Original languageEnglish (US)
Pages (from-to)40-46
Number of pages7
JournalCurrent Opinion in Biotechnology
Volume13
Issue number1
DOIs
StatePublished - Feb 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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