Lower rate-pressure product during submaximal walking: a link to fatigue improvement following a physical activity intervention among breast cancer survivors

Stephen J. Carter, Gary R. Hunter, Edward McAuley, Kerry S. Courneya, Philip M. Anton, Laura Q. Rogers

Research output: Contribution to journalArticle

Abstract

Purpose: Research showing a link between exercise-induced changes in aerobic fitness and reduced fatigue after a cancer diagnosis has been inconsistent. We evaluated associations of fatigue and rate-pressure product (RPP), a reliable index of myocardial oxygen demand, at rest and during submaximal walking following a physical activity intervention among post-primary treatment breast cancer survivors (BCS). Methods: Secondary analyses of 152 BCS in a randomized controlled trial testing a physical activity intervention (INT) versus usual care (UC) were performed. The INT group completed counseling/group discussions along with supervised exercise sessions tapered to unsupervised exercise. Evaluations were made at baseline and immediately post-intervention (M3) on measures of physical activity (accelerometry), graded walk test, and average fatigue over the previous 7 days. RPP was calculated by dividing the product of heart rate and systolic blood pressure by 100. Results: Resting and submaximal RPPs were significantly improved in both groups at M3; however, the magnitude of change (∆) was greater in the INT group from stage 1 (∆RPP1; INT −13 ± 17 vs. UC −7 ± 18; p = 0.03) through stage 4 (∆RPP4; INT −21 ± 26 vs. UC −9 ± 24; p < 0.01) of the walk test. The INT group reported significantly reduced fatigue (INT −0.7 ± 2.0 vs. UC +0.1 ± 2.0; p = 0.02) which was positively associated with ∆RPP during stages 2–4 of the walk test but not ∆aerobic fitness. Conclusions: Lower RPP during submaximal walking was significantly associated with reduced fatigue in BCS. Implications for Cancer Survivors: Exercise/physical activity training programs that lower the physiological strain during submaximal walking may produce the largest improvements in reported fatigue.

Original languageEnglish (US)
Pages (from-to)927-934
Number of pages8
JournalJournal of Cancer Survivorship
Volume10
Issue number5
DOIs
StatePublished - Oct 1 2016

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Walking
Fatigue
Breast Neoplasms
Pressure
Accelerometry
Blood Pressure
Counseling
Neoplasms
Randomized Controlled Trials
Heart Rate
Oxygen
Education
Research
Walk Test

Keywords

  • Cardiovascular
  • Exercise
  • Heart rate
  • Systolic blood pressure

ASJC Scopus subject areas

  • Oncology
  • Oncology(nursing)

Cite this

Lower rate-pressure product during submaximal walking : a link to fatigue improvement following a physical activity intervention among breast cancer survivors. / Carter, Stephen J.; Hunter, Gary R.; McAuley, Edward; Courneya, Kerry S.; Anton, Philip M.; Rogers, Laura Q.

In: Journal of Cancer Survivorship, Vol. 10, No. 5, 01.10.2016, p. 927-934.

Research output: Contribution to journalArticle

Carter, Stephen J. ; Hunter, Gary R. ; McAuley, Edward ; Courneya, Kerry S. ; Anton, Philip M. ; Rogers, Laura Q. / Lower rate-pressure product during submaximal walking : a link to fatigue improvement following a physical activity intervention among breast cancer survivors. In: Journal of Cancer Survivorship. 2016 ; Vol. 10, No. 5. pp. 927-934.
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AU - Anton, Philip M.

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AB - Purpose: Research showing a link between exercise-induced changes in aerobic fitness and reduced fatigue after a cancer diagnosis has been inconsistent. We evaluated associations of fatigue and rate-pressure product (RPP), a reliable index of myocardial oxygen demand, at rest and during submaximal walking following a physical activity intervention among post-primary treatment breast cancer survivors (BCS). Methods: Secondary analyses of 152 BCS in a randomized controlled trial testing a physical activity intervention (INT) versus usual care (UC) were performed. The INT group completed counseling/group discussions along with supervised exercise sessions tapered to unsupervised exercise. Evaluations were made at baseline and immediately post-intervention (M3) on measures of physical activity (accelerometry), graded walk test, and average fatigue over the previous 7 days. RPP was calculated by dividing the product of heart rate and systolic blood pressure by 100. Results: Resting and submaximal RPPs were significantly improved in both groups at M3; however, the magnitude of change (∆) was greater in the INT group from stage 1 (∆RPP1; INT −13 ± 17 vs. UC −7 ± 18; p = 0.03) through stage 4 (∆RPP4; INT −21 ± 26 vs. UC −9 ± 24; p < 0.01) of the walk test. The INT group reported significantly reduced fatigue (INT −0.7 ± 2.0 vs. UC +0.1 ± 2.0; p = 0.02) which was positively associated with ∆RPP during stages 2–4 of the walk test but not ∆aerobic fitness. Conclusions: Lower RPP during submaximal walking was significantly associated with reduced fatigue in BCS. Implications for Cancer Survivors: Exercise/physical activity training programs that lower the physiological strain during submaximal walking may produce the largest improvements in reported fatigue.

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