Low-molecular-weight chromium-binding substance from chicken liver and American alligator liver

M. Jason Hatfield, Shanna Gillespie, Yuan Chen, Zhong Li, Carolyn J. Cassady, John B. Vincent

Research output: Contribution to journalArticle


Low-molecular-weight chromium-binding substance (LMWCr), also known as chromodulin, is a chromium-binding oligopeptide proposed to have a function in chromium transport and insulin signaling in mammals. In this work, LMWCr has been isolated and purified for the first time from non-mammalian sources: chicken and American alligator. Milligram quantities of the oligopeptide can be obtained from kilogram quantities of liver. The LMWCr's from both sources are asparatate- and glutamate-rich oligopeptides which possess multinuclear chromium assemblies. The composition and physical and spectroscopic properties of the avian and reptilian LMWCr's are extremely similar to those of their mammalian analogues, suggesting the multinuclear sites of the biomolecule from all three classes of animal possess very similar structures. The chicken and alligator oligopeptides may possess intrinsic phosphotyrosine phosphatase activity.

Original languageEnglish (US)
Pages (from-to)423-431
Number of pages9
JournalComparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
Issue number4
StatePublished - Aug 2006
Externally publishedYes


  • Alligator
  • Chicken
  • Chromium
  • Chromodulin
  • Low-molecular-weight chromium-binding substance

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology

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