Low dose of kyotorphin (tyrosine-arginine) induces nociceptive responses through a substance P release from nociceptor endings

Makoto Inoue, Tomoko Yamada, Hiroshi Ueda

Research output: Contribution to journalArticlepeer-review

Abstract

The intraplantar injection of kyotorphin (Kyo) elicited nociceptive flexor responses in mice in a dose-dependent manner between 0.1 and 100 fmol. These actions were completely blocked by substance P (NK1) receptor antagonists, such as CP-96345 and CP-99994, but not by their inactive derivatives, CP-96344 or CP-100263, nor by MEN-10376, an NK2 antagonist. Kyo-responses were also abolished by the local pretreatment with capsaicin to deplete substance P from nociceptor endings, and in tachykinin 1 gene K/O mice. These findings suggest that Kyo indirectly stimulates nociceptor endings through a local substance P release. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)302-305
Number of pages4
JournalMolecular Brain Research
Volume69
Issue number2
DOIs
StatePublished - Jun 8 1999
Externally publishedYes

Keywords

  • Kyotorphin
  • Nociceptor endings
  • Substance P

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Fingerprint

Dive into the research topics of 'Low dose of kyotorphin (tyrosine-arginine) induces nociceptive responses through a substance P release from nociceptor endings'. Together they form a unique fingerprint.

Cite this