Abstract
The intraplantar injection of kyotorphin (Kyo) elicited nociceptive flexor responses in mice in a dose-dependent manner between 0.1 and 100 fmol. These actions were completely blocked by substance P (NK1) receptor antagonists, such as CP-96345 and CP-99994, but not by their inactive derivatives, CP-96344 or CP-100263, nor by MEN-10376, an NK2 antagonist. Kyo-responses were also abolished by the local pretreatment with capsaicin to deplete substance P from nociceptor endings, and in tachykinin 1 gene K/O mice. These findings suggest that Kyo indirectly stimulates nociceptor endings through a local substance P release. Copyright (C) 1999 Elsevier Science B.V.
Original language | English (US) |
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Pages (from-to) | 302-305 |
Number of pages | 4 |
Journal | Molecular Brain Research |
Volume | 69 |
Issue number | 2 |
DOIs | |
State | Published - Jun 8 1999 |
Externally published | Yes |
Keywords
- Kyotorphin
- Nociceptor endings
- Substance P
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience