Lost in transition: Dynamic enhancer organization across naive and primed stem cell states

Kevin Van Bortle; Victor G. Corces

doi:10.1016/j.stem.2014.05.004

Lost in transition: Dynamic enhancer organization across naive and primed stem cell states

Research output: Contribution to journal › Short survey › peer-review

Abstract

Pluripotent stem cells transition between distinct naive and primed states that are controlled by overlapping sets of master regulatory transcription factors. In this issue of Cell Stem Cell, Buecker et al. (2014) and Factor et al. (2014) demonstrate that alternate enhancer usage, regulated by state-specific binding partners of master regulators, defines these pluripotent state transitions.

Original language	English (US)
Pages (from-to)	693-694
Number of pages	2
Journal	Cell Stem Cell
Volume	14
Issue number	6
DOIs	https://doi.org/10.1016/j.stem.2014.05.004
State	Published - Jun 5 2014
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

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10.1016/j.stem.2014.05.004

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abstract = "Pluripotent stem cells transition between distinct naive and primed states that are controlled by overlapping sets of master regulatory transcription factors. In this issue of Cell Stem Cell, Buecker et al. (2014) and Factor et al. (2014) demonstrate that alternate enhancer usage, regulated by state-specific binding partners of master regulators, defines these pluripotent state transitions.",

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AU - Van Bortle, Kevin

AU - Corces, Victor G.

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N2 - Pluripotent stem cells transition between distinct naive and primed states that are controlled by overlapping sets of master regulatory transcription factors. In this issue of Cell Stem Cell, Buecker et al. (2014) and Factor et al. (2014) demonstrate that alternate enhancer usage, regulated by state-specific binding partners of master regulators, defines these pluripotent state transitions.

AB - Pluripotent stem cells transition between distinct naive and primed states that are controlled by overlapping sets of master regulatory transcription factors. In this issue of Cell Stem Cell, Buecker et al. (2014) and Factor et al. (2014) demonstrate that alternate enhancer usage, regulated by state-specific binding partners of master regulators, defines these pluripotent state transitions.

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Lost in transition: Dynamic enhancer organization across naive and primed stem cell states

Abstract

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