Longitudinal measurement invariance of the Multiple Sclerosis Walking Scale-12

Robert W. Motl, Edward McAuley, Sean Mullen

Research output: Contribution to journalArticlepeer-review


Objective: One primary assumption underlying the unambiguous interpretation of change in Multiple Sclerosis Walking Scale-12 (MSWS-12) scores over time is longitudinal measurement invariance (i.e., Is the same construct being measured over time?). Such an assumption was tested in the present study over periods of 6 and 12 months in persons with relapsing-remitting multiple sclerosis (RRMS). Method: Participants completed a battery of questionnaires that included the MSWS-12 at baseline (n = 269) and 6-months (n = 260) and 12-months (n = 252) follow-up. The data were analyzed using confirmatory factor analysis and a series of nested model comparisons in Mplus 3.0. Results: The results indicated that the unidimensional measurement model and all of its parameters (e.g., factor loadings and item intercepts) were invariant over periods of 6 and 12 months. Conclusion: We provide novel evidence that supports the unambiguous interpretation of scores from the MSWS-12 as a measure of change in walking impairment over time in a sample of persons with MS.

Original languageEnglish (US)
Pages (from-to)75-79
Number of pages5
JournalJournal of the Neurological Sciences
Issue number1-2
StatePublished - Jun 15 2011


  • Invariance
  • Measurement
  • Multiple sclerosis
  • Walking

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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