Long-term persistent infection of swine monocytes/macrophages with African swine fever virus

C. Carrillo, M. V. Borca, C. L. Afonso, D. V. Onisk, D. L. Rock

Research output: Contribution to journalArticlepeer-review

Abstract

Long-term persistent infection was established in 100% of pigs (n = 19) experimentally infected with African swine fever virus (ASFV). Viral DNA was detected in peripheral blood mononuclear leukocytes (PBML) at greater than 500 days postinfection by a PCR assay. Infectious virus was not, however, isolated from the same PBML samples. In cell fractionation studies of PBML, monocytes macrophages were found to harbor viral DNA during the persistent phase of infection. This result indicates that monocytes/macrophages are persistently infected with ASFV and that ASFV-swine monocyte/macrophage interactions can result in either lytic or persistent infection.

Original languageEnglish (US)
Pages (from-to)580-583
Number of pages4
JournalJournal of virology
Volume68
Issue number1
StatePublished - Jan 1994
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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