@article{d2628b2287874ff4ba58a1c4f83efa53,
title = "Long-term neural and physiological phenotyping of a single human",
abstract = "Psychiatric disorders are characterized by major fluctuations in psychological function over the course of weeks and months, but the dynamic characteristics of brain function over this timescale in healthy individuals are unknown. Here, as a proof of concept to address this question, we present the MyConnectome project. An intensive phenome-wide assessment of a single human was performed over a period of 18 months, including functional and structural brain connectivity using magnetic resonance imaging, psychological function and physical health, gene expression and metabolomics. A reproducible analysis workflow is provided, along with open access to the data and an online browser for results. We demonstrate dynamic changes in brain connectivity over the timescales of days to months, and relations between brain connectivity, gene expression and metabolites. This resource can serve as a testbed to study the joint dynamics of human brain and metabolic function over time, an approach that is critical for the development of precision medicine strategies for brain disorders.",
author = "Poldrack, {Russell A.} and Laumann, {Timothy O.} and Oluwasanmi Koyejo and Brenda Gregory and Ashleigh Hover and Chen, {Mei Yen} and Gorgolewski, {Krzysztof J.} and Jeffrey Luci and Joo, {Sung Jun} and Boyd, {Ryan L.} and Scott Hunicke-Smith and Simpson, {Zack Booth} and Thomas Caven and Vanessa Sochat and Shine, {James M.} and Evan Gordon and Snyder, {Abraham Z.} and Babatunde Adeyemo and Petersen, {Steven E.} and Glahn, {David C.} and Mckay, {D. Reese} and Curran, {Joanne E.} and G{\"o}ring, {Harald H.H.} and Carless, {Melanie A.} and John Blangero and Robert Dougherty and Alexander Leemans and Handwerker, {Daniel A.} and Laurie Frick and Marcotte, {Edward M.} and Mumford, {Jeanette A.}",
note = "Funding Information: This research was supported by the Texas Emerging Technology Fund (to Daniel Johnston, PI), James S. McDonnell Foundation Collaborative Activity award (to S.E.P.), National Institutes of Health (MH100872 to T.L., NS0046424 to S.E.P., GM076536 and OD009572 to E.M.M., MH078143 to D.G., MH078111 to J.B., MH083824 to D.G. and J.B.), National Science Foundation (1131441 to R.A.P., 1237975 to E.M.M.), Netherlands Organisation for Scientific Research (VIDI Grant 639.072.411 to A.L.), Welch Foundation (F1515 to E.M.M.), Australian National Health and Medical Research Council (GNT1072403 to J.M.S.), William R. Hewlett Stanford Graduate Fellowship (to V.S.) and the Cancer Prevention Research Institute of Texas (to E.M.M.). REDCap at UT is supported by 5R24HD042849 awarded to the Population Research Center at UT Austin. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Thanks to Neeta Bakhta for assistance with blood draws and laboratory analyses, Terry Heckman and Margaret Lutz for processing of blood samples, Dhivya Arasappan for assistance with bioinformatics, Joan Balash for assistance with audiometry, and Jacy Anthis, Ashley Armenita, Adiel Carlo, Andrew Coulter, Jave Del Rosario, Dustin Fry, Kristie Garza, Kelly Jameson, Seorin Kim, Christina Leuker, Lakshya Nagar, Jacob Perez, Grace Shearrer and Sheila Zare for assistance with MRI scanning. Thanks to Kalanit Grill-Spector, Anthony Stigliani and Evelina Federenko for providing localizer task software. We also thank the following individuals for helpful discussion and assistance at various points in the project: Tim Behrens, Robert Bilder, Randy Buckner, Rui Chen, Eliza Congdon, Maude David, George Georgiou, Matt Glasser, Steve Hanson, Alex Huk, Saad Jbabdi, Michael Milham, Nolan Nichols, Tom Nichols, James Pennebaker, Katie Pollard, Rajeev Raizada, Tom Schonberg, Michael Snyder, Stamatios Sotiropoulos, Emily Tsang, David Van Essen, Gael Varoquaux and Michael Waskom.",
year = "2015",
month = dec,
day = "9",
doi = "10.1038/ncomms9885",
language = "English (US)",
volume = "6",
journal = "Nature communications",
issn = "2041-1723",
publisher = "Nature Research",
}