Long-term evolution of viruses: A Janus-faced balance

Arshan Nasir, Kyung Mo Kim, Gustavo Caetano-Anolles

Research output: Contribution to journalReview article

Abstract

The popular textbook image of viruses as noxious and selfish genetic parasites greatly underestimates the beneficial contributions of viruses to the biosphere. Given the crucial dependency of viruses to reproduce in an intracellular environment, viruses that engage in excessive killing (lysis) can drive their cellular hosts to extinction and will not survive. The lytic mode of virus propagation must, therefore, be tempered and balanced by non-lytic modes of virus latency and symbiosis. Here, we review recent bioinformatics and metagenomic studies to argue that viral endogenization and domestication may be more frequent mechanisms of virus persistence than lysis. We use a triangle diagram to explain the three major virus persistence strategies that explain the global scope of virus-cell interactions including lysis, latency and virus-cell symbiosis. This paradigm can help identify novel directions in virology research where scientists could artificially gain control over switching lytic and beneficial viral lifestyles. Also see the Video Abstract: http://youtu.be/GwXWz4N8o8.

Original languageEnglish (US)
Article number1700026
JournalBioEssays
Volume39
Issue number8
DOIs
StatePublished - Aug 2017

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Long Term Evolution (LTE)
Viruses
Virus Latency
Symbiosis
Metagenomics
Virology
Textbooks
Computational Biology
Cell Communication
Gain control
Life Style
Bioinformatics
Parasites
Research

Keywords

  • beneficial viruses
  • persistence triangle
  • viral domestication
  • viral endogenization
  • virus-host interactions

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Long-term evolution of viruses : A Janus-faced balance. / Nasir, Arshan; Kim, Kyung Mo; Caetano-Anolles, Gustavo.

In: BioEssays, Vol. 39, No. 8, 1700026, 08.2017.

Research output: Contribution to journalReview article

Nasir, Arshan ; Kim, Kyung Mo ; Caetano-Anolles, Gustavo. / Long-term evolution of viruses : A Janus-faced balance. In: BioEssays. 2017 ; Vol. 39, No. 8.
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