Long-term effects of dietary olive oil and hydrogenated vegetable oil on expression of lipogenic genes in subcutaneous adipose tissue of dairy cows

Einar Vargas-Bello-Pérez, Massimo Bionaz, Pietro Sciarresi-Arechabala, Nathaly Cancino-Padilla, María Sol Morales, Jaime Romero, Heidi Leskinen, Philip C. Garnsworthy, Juan J. Loor

Research output: Contribution to journalArticle

Abstract

The objective of this study was to characterize the long-term transcriptomic effects of lipogenic genes in subcutaneous adipose tissue (SAT) of dairy cows supplemented with unsaturated (olive oil; OO) and saturated (hydrogenated vegetable oil; HVO) lipids. Cows were fed a control diet with no added lipid, or diets containing OO or HVO (n = 5 cows/group) for 63 days. SAT was obtained from the tail-head area at the onset of the study and after 21, 42, and 63 days of supplementation. Treatments had minor effects on expression of measured genes. Both fat supplements reduced expression of PPARG, HVO decreased transcription of the desaturase FADS2 and lipid droplet formation PLIN2, and OO increased transcription of FABP3. Both lipid treatments decreased expression of the transcription regulator SREBF1 and its chaperone (SCAP) during the first 21 days of treatment. Our data indicated that long-term feeding of OO and HVO have a relatively mild effect on expression of lipogenic genes in SAT of mid-lactating cows.

Original languageEnglish (US)
Article number74
JournalVeterinary Sciences
Volume6
Issue number3
DOIs
StatePublished - Jan 1 2019

Keywords

  • Adipose tissue
  • Dairy cows
  • Fat supplementation
  • Lipid metabolism
  • Lipogenic gene expression
  • Transcriptomics

ASJC Scopus subject areas

  • veterinary(all)

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    Vargas-Bello-Pérez, E., Bionaz, M., Sciarresi-Arechabala, P., Cancino-Padilla, N., Morales, M. S., Romero, J., Leskinen, H., Garnsworthy, P. C., & Loor, J. J. (2019). Long-term effects of dietary olive oil and hydrogenated vegetable oil on expression of lipogenic genes in subcutaneous adipose tissue of dairy cows. Veterinary Sciences, 6(3), [74]. https://doi.org/10.3390/vetsci6030074