Abstract
A surface force apparatus was used to measure a long-range attractive protein-ligand force at separations D < 85 angstroms. This force may effectively "steer" ligand trajectories, resulting in a greater than 27-fold enhancement of the association rate. A much stronger specific attraction is measured at contact (D < 4 angstroms). A sevenfold increase in intermembrane adhesion resulted from increased lateral mobility of the receptors and molecular rearrangements in membranes above the solid-fluid transition temperature.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1419-1421 |
| Number of pages | 3 |
| Journal | Science |
| Volume | 255 |
| Issue number | 5050 |
| State | Published - Mar 13 1992 |
| Externally published | Yes |
ASJC Scopus subject areas
- General