Long-range attraction and molecular rearrangements in receptor-ligand interactions

D. E. Leckband, J. N. Israelachvili, F. J. Schmitt, W. Knoll

Research output: Contribution to journalArticlepeer-review


A surface force apparatus was used to measure a long-range attractive protein-ligand force at separations D < 85 angstroms. This force may effectively "steer" ligand trajectories, resulting in a greater than 27-fold enhancement of the association rate. A much stronger specific attraction is measured at contact (D < 4 angstroms). A sevenfold increase in intermembrane adhesion resulted from increased lateral mobility of the receptors and molecular rearrangements in membranes above the solid-fluid transition temperature.

Original languageEnglish (US)
Pages (from-to)1419-1421
Number of pages3
Issue number5050
StatePublished - Mar 13 1992
Externally publishedYes

ASJC Scopus subject areas

  • General


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