Long-Distance Cooperative and Antagonistic RNA Polymerase Dynamics via DNA Supercoiling

Sangjin Kim; Bruno Beltran; Irnov Irnov; Christine Jacobs-Wagner

doi:10.1016/j.cell.2019.08.033

Long-Distance Cooperative and Antagonistic RNA Polymerase Dynamics via DNA Supercoiling

Sangjin Kim
, Bruno Beltran
, Irnov Irnov
, Christine Jacobs-Wagner

Research output: Contribution to journal › Article › peer-review

Abstract

Supercoiling introduced into DNA strands during the process of transcription influences other transcribing RNA polymerases over long distances, providing a physical basis for cooperative and antagonistic polymerase group behaviors.

Original language	English (US)
Pages (from-to)	106-119.e16
Journal	Cell
Volume	179
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2019.08.033
State	Published - Sep 19 2019
Externally published	Yes

Keywords

DNA supercoiling
RNA polymerase
gene regulation
group dynamics
premature termination
transcription elongation

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Online availability

10.1016/j.cell.2019.08.033

Library availability

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title = "Long-Distance Cooperative and Antagonistic RNA Polymerase Dynamics via DNA Supercoiling",

abstract = "Supercoiling introduced into DNA strands during the process of transcription influences other transcribing RNA polymerases over long distances, providing a physical basis for cooperative and antagonistic polymerase group behaviors.",

keywords = "DNA supercoiling, RNA polymerase, gene regulation, group dynamics, premature termination, transcription elongation",

author = "Sangjin Kim and Bruno Beltran and Irnov Irnov and Christine Jacobs-Wagner",

note = "We thank Drs. Carol Gross, Jonathan Weissman, Matthew Larson, Hendrik Osadnik, and Jeff Hussmann for helpful discussions and technical help; Drs. Samuel Kou and Andrei Kuzminov for useful suggestions; Drs. Wayne Wade and Jeorg Bewersdorf for materials; and Dr. Andrew Goodman for allowing us to use his real-time PCR machine. We also thank Dr. Patricia Rosa and the members of the Jacobs-Wagner laboratory for discussions and critical reading of the manuscript. C.J.-W. is an Investigator of the Howard Hughes Medical Institute. S.K. and C.J.-W. designed the study. S.K. performed experiments, and S.K. B.B. and C.J.-W. analyzed and discussed the data. S.K. B.B. and. I.I. provided resources. S.K. and C.J.-W. wrote the manuscript. All authors contributed to its editing. The authors declare no competing interests.",

year = "2019",

month = sep,

day = "19",

doi = "10.1016/j.cell.2019.08.033",

language = "English (US)",

volume = "179",

pages = "106--119.e16",

journal = "Cell",

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TY - JOUR

T1 - Long-Distance Cooperative and Antagonistic RNA Polymerase Dynamics via DNA Supercoiling

AU - Kim, Sangjin

AU - Beltran, Bruno

AU - Irnov, Irnov

AU - Jacobs-Wagner, Christine

N1 - We thank Drs. Carol Gross, Jonathan Weissman, Matthew Larson, Hendrik Osadnik, and Jeff Hussmann for helpful discussions and technical help; Drs. Samuel Kou and Andrei Kuzminov for useful suggestions; Drs. Wayne Wade and Jeorg Bewersdorf for materials; and Dr. Andrew Goodman for allowing us to use his real-time PCR machine. We also thank Dr. Patricia Rosa and the members of the Jacobs-Wagner laboratory for discussions and critical reading of the manuscript. C.J.-W. is an Investigator of the Howard Hughes Medical Institute. S.K. and C.J.-W. designed the study. S.K. performed experiments, and S.K. B.B. and C.J.-W. analyzed and discussed the data. S.K. B.B. and. I.I. provided resources. S.K. and C.J.-W. wrote the manuscript. All authors contributed to its editing. The authors declare no competing interests.

PY - 2019/9/19

Y1 - 2019/9/19

N2 - Supercoiling introduced into DNA strands during the process of transcription influences other transcribing RNA polymerases over long distances, providing a physical basis for cooperative and antagonistic polymerase group behaviors.

AB - Supercoiling introduced into DNA strands during the process of transcription influences other transcribing RNA polymerases over long distances, providing a physical basis for cooperative and antagonistic polymerase group behaviors.

KW - DNA supercoiling

KW - RNA polymerase

KW - gene regulation

KW - group dynamics

KW - premature termination

KW - transcription elongation

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UR - https://www.scopus.com/pages/publications/85071954773#tab=citedBy

U2 - 10.1016/j.cell.2019.08.033

DO - 10.1016/j.cell.2019.08.033

M3 - Article

C2 - 31539491

AN - SCOPUS:85071954773

SN - 0092-8674

VL - 179

SP - 106-119.e16

JO - Cell

JF - Cell

IS - 1

ER -

Long-Distance Cooperative and Antagonistic RNA Polymerase Dynamics via DNA Supercoiling

Abstract

Keywords

ASJC Scopus subject areas

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