Long-Distance Cooperative and Antagonistic RNA Polymerase Dynamics via DNA Supercoiling

Sangjin Kim; Bruno Beltran; Irnov Irnov; Christine Jacobs-Wagner

doi:10.1016/j.cell.2019.08.033

Long-Distance Cooperative and Antagonistic RNA Polymerase Dynamics via DNA Supercoiling

Sangjin Kim, Bruno Beltran, Irnov Irnov, Christine Jacobs-Wagner

Research output: Contribution to journal › Article › peer-review

Abstract

Supercoiling introduced into DNA strands during the process of transcription influences other transcribing RNA polymerases over long distances, providing a physical basis for cooperative and antagonistic polymerase group behaviors.

Original language	English (US)
Pages (from-to)	106-119.e16
Journal	Cell
Volume	179
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2019.08.033
State	Published - Sep 19 2019
Externally published	Yes

Keywords

DNA supercoiling
RNA polymerase
gene regulation
group dynamics
premature termination
transcription elongation

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2019.08.033

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title = "Long-Distance Cooperative and Antagonistic RNA Polymerase Dynamics via DNA Supercoiling",

abstract = "Supercoiling introduced into DNA strands during the process of transcription influences other transcribing RNA polymerases over long distances, providing a physical basis for cooperative and antagonistic polymerase group behaviors.",

keywords = "DNA supercoiling, RNA polymerase, gene regulation, group dynamics, premature termination, transcription elongation",

author = "Sangjin Kim and Bruno Beltran and Irnov Irnov and Christine Jacobs-Wagner",

year = "2019",

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KW - group dynamics

KW - premature termination

KW - transcription elongation

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