Long-Distance Cooperative and Antagonistic RNA Polymerase Dynamics via DNA Supercoiling

Sangjin Kim, Bruno Beltran, Irnov Irnov, Christine Jacobs-Wagner

Research output: Contribution to journalArticlepeer-review

Abstract

Supercoiling introduced into DNA strands during the process of transcription influences other transcribing RNA polymerases over long distances, providing a physical basis for cooperative and antagonistic polymerase group behaviors.

Original languageEnglish (US)
Pages (from-to)106-119.e16
JournalCell
Volume179
Issue number1
DOIs
StatePublished - Sep 19 2019
Externally publishedYes

Keywords

  • DNA supercoiling
  • RNA polymerase
  • gene regulation
  • group dynamics
  • premature termination
  • transcription elongation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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