Long-circulating QD probes for in-vivo tumor imaging

Xiaohu Gao, Shuming Nie

Research output: Contribution to journalConference articlepeer-review


Biocompatible semiconductor quantum dot (QD) probes with extended plasma circulating times have been developed for cancer imaging in living animals. The structural design involves encapsulating luminescent QDs with a triblock copolymer, and linking this amphiphilic polymer to multiple poly(ethylene glycol) (PEG) molecules. In vitro histology and in vivo imaging studies indicate that the QD probes can be delivered to tumor sites by enhanced permeation and retention. Using both systemic injection of long-circulating QD probes and subcutaneous injection of QD-tagged microbeads, we have achieved sensitive and multicolor fluorescence imaging of cancer cells under in vivo conditions. These results raise new possibilities for ultrasensitive and multiplexed imaging of molecular targets in vivo.

Original languageEnglish (US)
Article number47
Pages (from-to)292-299
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2004
Externally publishedYes
EventNanosensing Materials and Devices - Philadelphia, PA, United States
Duration: Oct 25 2004Oct 28 2004


  • Fluorescence
  • Long circulating
  • Molecular imaging
  • Multicolor
  • Nanoparticles
  • Probes
  • Quantum dots
  • Targeting

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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