Localized heating on silicon field effect transistors for bio-chemical reactions

We demonstrate the temperature mediated applications of a previously proposed novel localized dielectric heating method on the surface of a silicon field effect transistor and perform modeling and characterization of the underlying mechanisms. Two important applications spanning different temperature ranges are shown: a heat-mediated DNA exchange reaction and the complete desorption and reattachment of chemical functionalization from the transistor surfaces for biosensor platforms. Our results show that the use of silicon transistors can be extended beyond electrical switching and field-effect sensing to performing ultra-localized temperature controlled chemical reactions on the transistor itself.