TY - JOUR
T1 - Localization of the locus causing Spider Lamb Syndrome to the distal end of ovine Chromosome 6
AU - Cockett, N. E.
AU - Shay, T. L.
AU - Beever, J. E.
AU - Nielsen, D.
AU - Albretsen, J.
AU - Georges, M.
AU - Peterson, K.
AU - Stephens, A.
AU - Vernon, W.
AU - Timofeevskaia, O.
AU - South, S.
AU - Mork, J.
AU - Maciulis, A.
AU - Bunch, T. D.
PY - 1999
Y1 - 1999
N2 - Spider Lamb Syndrome (SLS) is a semi-lethal congenital disorder, causing severe skeletal abnormalities in sheep. The syndrome has now been disseminated into several sheep breeds in the United States, Canada, and Australia. The mode of inheritance for SLS is autosomal recessive, making the identification and culling of carrier animals difficult due to their normal phenotype. Two large pedigrees segregating for the SLS mutation were established, and a genome scan with genetic markers from previously published genome maps of cattle and sheep was used to map the locus causing SLS. Genetic linkage between SLS and several microsatellite markers, OarJMP8, McM214, OarJMP12, and BL1038, was detected, thereby mapping the SLS locus to the telomeric end of ovine Chromosome (Chr) 6. Alignment of ovine Chr 6 with its evolutionary ortholog, human Chr 4, revealed a positional candidate gene, fibroblast growth factor receptor 3 (FGFR3).
AB - Spider Lamb Syndrome (SLS) is a semi-lethal congenital disorder, causing severe skeletal abnormalities in sheep. The syndrome has now been disseminated into several sheep breeds in the United States, Canada, and Australia. The mode of inheritance for SLS is autosomal recessive, making the identification and culling of carrier animals difficult due to their normal phenotype. Two large pedigrees segregating for the SLS mutation were established, and a genome scan with genetic markers from previously published genome maps of cattle and sheep was used to map the locus causing SLS. Genetic linkage between SLS and several microsatellite markers, OarJMP8, McM214, OarJMP12, and BL1038, was detected, thereby mapping the SLS locus to the telomeric end of ovine Chromosome (Chr) 6. Alignment of ovine Chr 6 with its evolutionary ortholog, human Chr 4, revealed a positional candidate gene, fibroblast growth factor receptor 3 (FGFR3).
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U2 - 10.1007/s003359900938
DO - 10.1007/s003359900938
M3 - Article
C2 - 9892730
AN - SCOPUS:0032768474
SN - 0938-8990
VL - 10
SP - 35
EP - 38
JO - Mammalian Genome
JF - Mammalian Genome
IS - 1
ER -