Localization of asymmetric brain function in emotion and depression

John D. Herrington, Wendy Heller, Aprajita Mohanty, Anna S. Engels, Marie T. Banich, Andrew G. Webb, Gregory A. Miller

Research output: Contribution to journalArticle


Although numerous EEG studies have shown that depression is associated with abnormal functional asymmetries in frontal cortex, fMRI and PET studies have largely failed to identify specific brain areas showing this effect. The present study tested the hypothesis that emotion processes are related to asymmetric patterns of fMRI activity, particularly within dorsolateral prefrontal cortex (DLPFC). Eleven depressed and 18 control participants identified the color in which pleasant, neutral, and unpleasant words were printed. Both groups showed a leftward lateralization for pleasant words in DLPFC. In a neighboring DLPFC area, the depression group showed more right-lateralized activation than controls, replicating EEG findings. These data confirm that emotional stimulus processing and trait depression are associated with asymmetric brain functions in distinct subregions of the DLPFC that may go undetected unless appropriate analytic procedures are used.

Original languageEnglish (US)
Pages (from-to)442-454
Number of pages13
Issue number3
StatePublished - May 1 2010


  • Brain asymmetry
  • Depression
  • Emotion
  • FMRI

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Neurology
  • Endocrine and Autonomic Systems
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Biological Psychiatry

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  • Cite this

    Herrington, J. D., Heller, W., Mohanty, A., Engels, A. S., Banich, M. T., Webb, A. G., & Miller, G. A. (2010). Localization of asymmetric brain function in emotion and depression. Psychophysiology, 47(3), 442-454. https://doi.org/10.1111/j.1469-8986.2009.00958.x