Localization of κ opioid receptors in oxytocin magnocellular neurons in the paraventricular and supraoptic nuclei

Matthew J. Smith, Phyllis M. Wise

    Research output: Contribution to journalArticlepeer-review

    Abstract

    It has been demonstrated previously that κ opioid receptor agonists, such as dynorphin, inhibit oxytocin secretion in the rat. To determine whether κ agonists act directly on oxytocin-containing magnocellular neurons to inhibit hormone secretion, we utilized immunofluorescence to examine the cellular localization of κ opioid receptors in the rat paraventricular and supraoptic nuclei. κ Opioid receptor immunoreactivity co-localized with oxytocin-containing cell bodies, their axons and axon terminals. Thus, our results suggest that κ opioid receptor agonists can exert direct inhibitory actions on oxytocin magnocellular neurons.

    Original languageEnglish (US)
    Pages (from-to)162-165
    Number of pages4
    JournalBrain Research
    Volume898
    Issue number1
    DOIs
    StatePublished - Apr 13 2001

    Keywords

    • Immunocytochemistry
    • Oxytocin
    • Posterior pituitary
    • κ Opioid receptor

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Molecular Biology
    • Clinical Neurology
    • Developmental Biology

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