Abstract

The identification and correction of wavefront aberrations is often necessary to achieve high-resolution optical images of biological tissues, as imperfections in the optical system and the tissue itself distort the imaging beam. Measuring the localized wavefront aberration provides information on where the beam is distorted and how severely. We have recently developed a method to estimate the single-pass wavefront aberrations from complex optical coherence tomography (OCT) data. Using this method, localized wavefront measurement and correction using computational OCT was performed in ex vivo tissues. The computationally measured wavefront varied throughout the imaged OCT volumes and, therefore, a local wavefront correction outperformed a global wavefront correction. The local wavefront measurement was also used to generate tissue aberration maps. Such aberration maps could potentially be used as a new form of tissue contrast.

Original languageEnglish (US)
Pages (from-to)1186-1189
Number of pages4
JournalOptics Letters
Volume44
Issue number5
DOIs
StatePublished - Mar 1 2019

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adaptive optics
aberration
tomography
high resolution
defects
estimates

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Local wavefront mapping in tissue using computational adaptive optics OCT. / South, Fredrick A.; Liu, Yuan Zhi; Huang, Pin Chieh; Kohlfarber, Tabea; Boppart, Stephen Allen.

In: Optics Letters, Vol. 44, No. 5, 01.03.2019, p. 1186-1189.

Research output: Contribution to journalArticle

South, Fredrick A. ; Liu, Yuan Zhi ; Huang, Pin Chieh ; Kohlfarber, Tabea ; Boppart, Stephen Allen. / Local wavefront mapping in tissue using computational adaptive optics OCT. In: Optics Letters. 2019 ; Vol. 44, No. 5. pp. 1186-1189.
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