Abstract
The identification and correction of wavefront aberrations is often necessary to achieve high-resolution optical images of biological tissues, as imperfections in the optical system and the tissue itself distort the imaging beam. Measuring the localized wavefront aberration provides information on where the beam is distorted and how severely. We have recently developed a method to estimate the single-pass wavefront aberrations from complex optical coherence tomography (OCT) data. Using this method, localized wavefront measurement and correction using computational OCT was performed in ex vivo tissues. The computationally measured wavefront varied throughout the imaged OCT volumes and, therefore, a local wavefront correction outperformed a global wavefront correction. The local wavefront measurement was also used to generate tissue aberration maps. Such aberration maps could potentially be used as a new form of tissue contrast.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1186-1189 |
| Number of pages | 4 |
| Journal | Optics Letters |
| Volume | 44 |
| Issue number | 5 |
| DOIs | |
| State | Published - Mar 1 2019 |
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ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
Cite this
Local wavefront mapping in tissue using computational adaptive optics OCT. / South, Fredrick A.; Liu, Yuan Zhi; Huang, Pin Chieh; Kohlfarber, Tabea; Boppart, Stephen Allen.
In: Optics Letters, Vol. 44, No. 5, 01.03.2019, p. 1186-1189.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Local wavefront mapping in tissue using computational adaptive optics OCT
AU - South, Fredrick A.
AU - Liu, Yuan Zhi
AU - Huang, Pin Chieh
AU - Kohlfarber, Tabea
AU - Boppart, Stephen Allen
PY - 2019/3/1
Y1 - 2019/3/1
N2 - The identification and correction of wavefront aberrations is often necessary to achieve high-resolution optical images of biological tissues, as imperfections in the optical system and the tissue itself distort the imaging beam. Measuring the localized wavefront aberration provides information on where the beam is distorted and how severely. We have recently developed a method to estimate the single-pass wavefront aberrations from complex optical coherence tomography (OCT) data. Using this method, localized wavefront measurement and correction using computational OCT was performed in ex vivo tissues. The computationally measured wavefront varied throughout the imaged OCT volumes and, therefore, a local wavefront correction outperformed a global wavefront correction. The local wavefront measurement was also used to generate tissue aberration maps. Such aberration maps could potentially be used as a new form of tissue contrast.
AB - The identification and correction of wavefront aberrations is often necessary to achieve high-resolution optical images of biological tissues, as imperfections in the optical system and the tissue itself distort the imaging beam. Measuring the localized wavefront aberration provides information on where the beam is distorted and how severely. We have recently developed a method to estimate the single-pass wavefront aberrations from complex optical coherence tomography (OCT) data. Using this method, localized wavefront measurement and correction using computational OCT was performed in ex vivo tissues. The computationally measured wavefront varied throughout the imaged OCT volumes and, therefore, a local wavefront correction outperformed a global wavefront correction. The local wavefront measurement was also used to generate tissue aberration maps. Such aberration maps could potentially be used as a new form of tissue contrast.
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U2 - 10.1364/OL.44.001186
DO - 10.1364/OL.44.001186
M3 - Article
VL - 44
SP - 1186
EP - 1189
JO - Optics Letters
JF - Optics Letters
SN - 0146-9592
IS - 5
ER -