Abstract

This study presents a "living" microvascular stamp that releases multiple angiogenic factors and subsequently creates functional neovessels with the same pattern as that engraved in the stamp. The stamp consists of live cells that secrete angiogenic factors, an engineered hydrogel matrix that promotes cellular expression of angiogenic factors, and a three-dimensional geometry that localizes the angiogenic factors within the pattern.

Original languageEnglish (US)
Pages (from-to)58-63
Number of pages6
JournalAdvanced Materials
Volume24
Issue number1
DOIs
StatePublished - Jan 3 2012

Keywords

  • angiogenesis
  • cell-encapsulation
  • methacrylic alginate
  • patterned neovessels
  • stereolithography

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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