TY - JOUR
T1 - Livestock variation of linked microsatellite markers in diverse swine breeds
AU - Paszek, A. A.
AU - Flickinger, G. H.
AU - Fontanesi, L.
AU - Rohrer, G. A.
AU - Alexander, L.
AU - Beattie, C. W.
AU - Schook, L. B.
N1 - Funding Information:
The support of the USDA National Research Initiatives-Competitive Research Grants Office (Grant
PY - 1998
Y1 - 1998
N2 - A panel of nine framework microsatellites (MS) linked to the Calcium Release Channel (CRC) locus on swine chromosome 6 (SSC6) was developed from the consensus genetic map. MS were screened across groups of unrelated animals from Yorkshire, Hampshire, Duroc, Landrace and Meishan swine breeds. Unique MS alleles for Yorkshire, Duroc, Landrace and Meishan breeds, and statistically significant (P<.05) associations between breeds and allele frequencies were found for each MS. Although breed marker heterosygosities ranged from 0.0 (S0035 in Duroc) to 0.92 (S0087 in Meishan), Correspondence Analysis identified MS alleles uniquely associated with either the Meishan breed, western breeds or alleles common to all breeds. Furthermore, an overall marker heterozygosity of <0.70 demonstrates the need for multiple MS panels to accommodate reduced within-breed differences for identification of quantitative trait loci (QTL), marker assisted selection (MAS) programs or parental identification in commercial breeds.
AB - A panel of nine framework microsatellites (MS) linked to the Calcium Release Channel (CRC) locus on swine chromosome 6 (SSC6) was developed from the consensus genetic map. MS were screened across groups of unrelated animals from Yorkshire, Hampshire, Duroc, Landrace and Meishan swine breeds. Unique MS alleles for Yorkshire, Duroc, Landrace and Meishan breeds, and statistically significant (P<.05) associations between breeds and allele frequencies were found for each MS. Although breed marker heterosygosities ranged from 0.0 (S0035 in Duroc) to 0.92 (S0087 in Meishan), Correspondence Analysis identified MS alleles uniquely associated with either the Meishan breed, western breeds or alleles common to all breeds. Furthermore, an overall marker heterozygosity of <0.70 demonstrates the need for multiple MS panels to accommodate reduced within-breed differences for identification of quantitative trait loci (QTL), marker assisted selection (MAS) programs or parental identification in commercial breeds.
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U2 - 10.1080/10495399809525892
DO - 10.1080/10495399809525892
M3 - Article
C2 - 9676235
AN - SCOPUS:0031613080
SN - 1049-5398
VL - 9
SP - 55
EP - 66
JO - Animal Biotechnology
JF - Animal Biotechnology
IS - 1
ER -