Littoral cell angiosarcoma in a dog

A. Gal, J. Yamate, H. M. Golbar, K. Spoerer, R. Fredrickson

Research output: Contribution to journalArticlepeer-review


This report describes the microscopical and immunohistochemical characteristics of littoral cell angiosarcoma in a 12-year-old, neutered female, beagle dog. The dog succumbed to metastatic disease 3 months after diagnosis of a mid-splenic mass. The tumour was characterized by two histological patterns: anastomosing microvascular channels and microvascular papillary fronds. The neoplastic cells expressed both endothelial and histiocytic markers and were erythrophagocytic. Immunohistochemical findings consistent with malignancy were CD34 expression and high Ki67 nuclear immunoreactivity.

Original languageEnglish (US)
Pages (from-to)221-224
Number of pages4
JournalJournal of Comparative Pathology
Issue number2-3
StatePublished - Aug 2013


  • Dog
  • Immunohistochemistry
  • Littoral cell angiosarcoma
  • Spleen

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • General Veterinary


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