TY - JOUR
T1 - Little heterogeneity among genes encoding heat-labile and heat-stable toxins of enterotoxigenic Escherichia coli strains isolated from diarrheal pigs
AU - Zhang, Chengxian
AU - Rausch, Dana
AU - Zhang, Weiping
PY - 2009/10
Y1 - 2009/10
N2 - To examine whether the heat-labile enterotoxin gene in porcine enterotoxigenic Escherichia coli (ETEC) strains is as divergent as in human ETEC strains, we sequenced the heat-labile and heat-stable toxin genes from 52 and 33 porcine ETEC strains, respectively. We found that the STa gene is identical, that the LT gene has only two mutations in 4 (of 52) strains, and that both mutations cause a reduction in GM1 binding and toxicity.
AB - To examine whether the heat-labile enterotoxin gene in porcine enterotoxigenic Escherichia coli (ETEC) strains is as divergent as in human ETEC strains, we sequenced the heat-labile and heat-stable toxin genes from 52 and 33 porcine ETEC strains, respectively. We found that the STa gene is identical, that the LT gene has only two mutations in 4 (of 52) strains, and that both mutations cause a reduction in GM1 binding and toxicity.
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U2 - 10.1128/AEM.00952-09
DO - 10.1128/AEM.00952-09
M3 - Article
C2 - 19684170
AN - SCOPUS:70349432281
SN - 0099-2240
VL - 75
SP - 6402
EP - 6405
JO - Applied and environmental microbiology
JF - Applied and environmental microbiology
IS - 19
ER -