Lipoic acid attachment to proteins: stimulating new developments

Research output: Contribution to journalReview articlepeer-review

Abstract

Lipoic acid-modified proteins are essential for central metabolism and pathogenesis. In recent years, the Escherichia coli and Bacillus subtilis lipoyl assembly pathways have been modified and extended to archaea and diverse eukaryotes including humans. These extensions include a new pathway to insert the key sulfur atoms of lipoate, several new pathways of lipoate salvage, and a novel use of lipoic acid in sulfur-oxidizing bacteria. Other advances are the modification of E. coli LplA for studies of protein localization and protein-protein interactions in cell biology and in enzymatic removal of lipoate from lipoyl proteins. Finally, scenarios have been put forth for the evolution of lipoate assembly in archaea.

Original languageEnglish (US)
JournalMicrobiology and Molecular Biology Reviews
Volume88
Issue number2
DOIs
StatePublished - Jun 2024

Keywords

  • lipoate ligase
  • lipoic acid
  • lipoyl relay
  • lipoyl synthase

ASJC Scopus subject areas

  • General Medicine

Fingerprint

Dive into the research topics of 'Lipoic acid attachment to proteins: stimulating new developments'. Together they form a unique fingerprint.

Cite this