Lipid-based liquid crystalline films and solutions for the delivery of cargo to cells

Marilyn Porras-Gomez, Cecilia Leal

Research output: Contribution to journalReview article

Abstract

A major challenge in the delivery of cargo (genes and/or drugs) to cells using nanostructured vehicles is the ability to safely penetrate plasma membranes by escaping the endosome before degradation, later releasing the payload into the cytoplasm or organelle of interest. Lipids are a class of bio-compatible molecules that self-assemble into a variety of liquid crystalline constructs. Most of these materials can be used to encapsulate drugs, proteins, and nucleic acids to deliver them safely into various cell types. Lipid phases offer a plethora of structures capable of forming complexes with biomolecules, most notably nucleic acids. The physichochemical characteristics of the lipid molecular building blocks, one might say the lipid primary structure, dictates how they collectively interact to assemble into various secondary structures. These include bilayers, lamellar stacks of bilayers, two-dimensional (2D) hexagonal arrays of lipid tubes, and even 3D cubic constructs. The liquid crystalline materials can be present in the form of aqueous suspensions, bulk materials or confined to a film configuration depending on the intended application (e.g. bolus vs surface-based delivery). This work compiles recent findings of different lipid-based liquid crystalline constructs both in films and particles for gene and drug delivery applications. We explore how lipid primary and secondary structures endow liquid crystalline materials with the ability to carry biomolecular cargo and interact with cells.

Original languageEnglish (US)
Pages (from-to)167-182
Number of pages16
JournalLiquid Crystals Reviews
Volume7
Issue number2
DOIs
StatePublished - Jul 3 2019

Fingerprint

cargo
Lipids
lipids
delivery
Crystalline materials
Liquids
liquids
cells
Liquid Crystals
drugs
Nucleic acids
nucleic acids
genes
Nucleic Acids
Genes
acids
organelles
cytoplasm
releasing
Biomolecules

Keywords

  • drug delivery
  • gene delivery
  • lipid films
  • lipid particles
  • Lipid-based liquid crystals
  • small molecules

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Lipid-based liquid crystalline films and solutions for the delivery of cargo to cells. / Porras-Gomez, Marilyn; Leal, Cecilia.

In: Liquid Crystals Reviews, Vol. 7, No. 2, 03.07.2019, p. 167-182.

Research output: Contribution to journalReview article

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