LIN-10 is a shared component of the polarized protein localization pathways in neurons and epithelia

Christopher Rongo, Charles W. Whitfield, Avital Rodal, Kim Stuart K, Joshua M. Kaplan

Research output: Contribution to journalArticlepeer-review

Abstract

We tested the model that neurons and epithelial cells use a shared mechanism for polarized protein sorting by comparing the pathways for localizing basolateral and postsynaptic proteins in C. elegans. GLR-1 glutamate receptors are localized to postsynaptic elements of central synapses and, when ectopically expressed, to basolateral membranes of epithelial cells. Proper localization of GLR-1 in both neurons and epithelia requires the PDZ protein LIN-10, defining LIN-10 as a shared component of the basolateral and postsynaptic localization pathways. Changing the GLR-1 carboxyterminal sequence from a group I PDZ-binding consensus (-TAV) to a group II consensus (-FYV) restores GLR-1 synaptic localization in lin-10 mutants. Thus, these interneurons utilize at least two separate postsynaptic localization pathways.

Original languageEnglish (US)
Pages (from-to)751-759
Number of pages9
JournalCell
Volume94
Issue number6
DOIs
StatePublished - Sep 18 1998

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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