Limited diversity of the rearranged T-cell γ gene

David M. Kranz, Haruo Saito, Mark Heller, Yohtaroh Takagaki, Werner Haas, Herman N. Eisen, Susumu Tonegawa

Research output: Contribution to journalArticlepeer-review

Abstract

The immunoglobulin-related, T-cell specific γ gene is rearranged in a wide variety of murine T lymphocytes. We detected γ-gene transcripts in all cloned cytotoxic T lymphocytes examined but in only 1 of 11 T-helper cell lines or hybridomas. Although in cytotoxic T cells, the rearranged γ gene seems to have been assembled from the same germ-line variable and joining gene segments, the transcribed gene exhibited distinct sequence diversity near the junction between these segments.

Original languageEnglish (US)
Pages (from-to)752-755
Number of pages4
JournalNature
Volume313
Issue number6005
DOIs
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • General

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