Limited diversity of the rearranged T-cell γ gene

David M Kranz, Haruo Saito, Mark Heller, Yohtaroh Takagaki, Werner Haas, Herman N. Eisen, Susumu Tonegawa

Research output: Contribution to journalArticle

Abstract

The immunoglobulin-related, T-cell specific γ gene is rearranged in a wide variety of murine T lymphocytes. We detected γ-gene transcripts in all cloned cytotoxic T lymphocytes examined but in only 1 of 11 T-helper cell lines or hybridomas. Although in cytotoxic T cells, the rearranged γ gene seems to have been assembled from the same germ-line variable and joining gene segments, the transcribed gene exhibited distinct sequence diversity near the junction between these segments.

Original languageEnglish (US)
Pages (from-to)752-755
Number of pages4
JournalNature
Volume313
Issue number6005
DOIs
StatePublished - Dec 1 1985
Externally publishedYes

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T-Lymphocytes
Genes
Hybridomas
Cytotoxic T-Lymphocytes
Germ Cells
Immunoglobulins
Cell Line

ASJC Scopus subject areas

  • General

Cite this

Kranz, D. M., Saito, H., Heller, M., Takagaki, Y., Haas, W., Eisen, H. N., & Tonegawa, S. (1985). Limited diversity of the rearranged T-cell γ gene. Nature, 313(6005), 752-755. https://doi.org/10.1038/313752a0

Limited diversity of the rearranged T-cell γ gene. / Kranz, David M; Saito, Haruo; Heller, Mark; Takagaki, Yohtaroh; Haas, Werner; Eisen, Herman N.; Tonegawa, Susumu.

In: Nature, Vol. 313, No. 6005, 01.12.1985, p. 752-755.

Research output: Contribution to journalArticle

Kranz, DM, Saito, H, Heller, M, Takagaki, Y, Haas, W, Eisen, HN & Tonegawa, S 1985, 'Limited diversity of the rearranged T-cell γ gene', Nature, vol. 313, no. 6005, pp. 752-755. https://doi.org/10.1038/313752a0
Kranz DM, Saito H, Heller M, Takagaki Y, Haas W, Eisen HN et al. Limited diversity of the rearranged T-cell γ gene. Nature. 1985 Dec 1;313(6005):752-755. https://doi.org/10.1038/313752a0
Kranz, David M ; Saito, Haruo ; Heller, Mark ; Takagaki, Yohtaroh ; Haas, Werner ; Eisen, Herman N. ; Tonegawa, Susumu. / Limited diversity of the rearranged T-cell γ gene. In: Nature. 1985 ; Vol. 313, No. 6005. pp. 752-755.
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