Limitations on estimation of effective scatterer diameters

Yang Zhu; Aiguo Han; William D. O'Brien; Michael L. Oelze; Michael F. Insana

doi:10.1121/1.5017602

Limitations on estimation of effective scatterer diameters

Yang Zhu, Aiguo Han, William D. O'Brien, Michael L. Oelze, Michael F. Insana

Research output: Contribution to journal › Article › peer-review

Abstract

The influence of spatial diversity in acoustic scattering properties on estimates of the effective scatterer diameter (ESD) applied to soft biological tissues is investigated. This study is based on two-dimensional simulations of scattering media, beginning with random distributions of simple disk structures where all scattering features are known exactly. It concludes with an analysis of histology maps from healthy and fatty rabbit liver. Further, the liver histology is decomposed using an orthonormal basis to separate acoustic scattering at various spatial scales and observe how it influences ESD estimates. Overall, the goal is to quantitatively interpret ESD results for diagnostic assessments despite wide variations in tissue scatterer properties.

Original language	English (US)
Pages (from-to)	3677-3690
Number of pages	14
Journal	Journal of the Acoustical Society of America
Volume	142
Issue number	6
DOIs	https://doi.org/10.1121/1.5017602
State	Published - Dec 1 2017

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Acoustics and Ultrasonics

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10.1121/1.5017602

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title = "Limitations on estimation of effective scatterer diameters",

abstract = "The influence of spatial diversity in acoustic scattering properties on estimates of the effective scatterer diameter (ESD) applied to soft biological tissues is investigated. This study is based on two-dimensional simulations of scattering media, beginning with random distributions of simple disk structures where all scattering features are known exactly. It concludes with an analysis of histology maps from healthy and fatty rabbit liver. Further, the liver histology is decomposed using an orthonormal basis to separate acoustic scattering at various spatial scales and observe how it influences ESD estimates. Overall, the goal is to quantitatively interpret ESD results for diagnostic assessments despite wide variations in tissue scatterer properties.",

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AU - Insana, Michael F.

PY - 2017/12/1

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AB - The influence of spatial diversity in acoustic scattering properties on estimates of the effective scatterer diameter (ESD) applied to soft biological tissues is investigated. This study is based on two-dimensional simulations of scattering media, beginning with random distributions of simple disk structures where all scattering features are known exactly. It concludes with an analysis of histology maps from healthy and fatty rabbit liver. Further, the liver histology is decomposed using an orthonormal basis to separate acoustic scattering at various spatial scales and observe how it influences ESD estimates. Overall, the goal is to quantitatively interpret ESD results for diagnostic assessments despite wide variations in tissue scatterer properties.

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Limitations on estimation of effective scatterer diameters

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