Limb development: A paradigm of gene regulation

Florence Petit, Karen E. Sears, Nadav Ahituv

Research output: Contribution to journalReview articlepeer-review


The limb is a commonly used model system for developmental biology. Given the need for precise control of complex signalling pathways to achieve proper patterning, the limb is also becoming a model system for gene regulation studies. Recent developments in genomic technologies have enabled the genome-wide identification of regulatory elements that control limb development, yielding insights into the determination of limb morphology and forelimb versus hindlimb identity. The modulation of regulatory interactions-for example, through the modification of regulatory sequences or chromatin architecture-can lead to morphological evolution, acquired regeneration capacity or limb malformations in diverse species, including humans.

Original languageEnglish (US)
Pages (from-to)245-258
Number of pages14
JournalNature Reviews Genetics
Issue number4
StatePublished - Apr 1 2017

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)


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