Limb development: A paradigm of gene regulation

Florence Petit, Karen Sears, Nadav Ahituv

Research output: Contribution to journalReview article

Abstract

The limb is a commonly used model system for developmental biology. Given the need for precise control of complex signalling pathways to achieve proper patterning, the limb is also becoming a model system for gene regulation studies. Recent developments in genomic technologies have enabled the genome-wide identification of regulatory elements that control limb development, yielding insights into the determination of limb morphology and forelimb versus hindlimb identity. The modulation of regulatory interactions-for example, through the modification of regulatory sequences or chromatin architecture-can lead to morphological evolution, acquired regeneration capacity or limb malformations in diverse species, including humans.

Original languageEnglish (US)
Pages (from-to)245-258
Number of pages14
JournalNature Reviews Genetics
Volume18
Issue number4
DOIs
StatePublished - Apr 1 2017

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Extremities
Genes
Developmental Biology
Systems Biology
Forelimb
Hindlimb
Chromatin
Regeneration
Genome
Technology

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Limb development : A paradigm of gene regulation. / Petit, Florence; Sears, Karen; Ahituv, Nadav.

In: Nature Reviews Genetics, Vol. 18, No. 4, 01.04.2017, p. 245-258.

Research output: Contribution to journalReview article

Petit, F, Sears, K & Ahituv, N 2017, 'Limb development: A paradigm of gene regulation', Nature Reviews Genetics, vol. 18, no. 4, pp. 245-258. https://doi.org/10.1038/nrg.2016.167
Petit, Florence ; Sears, Karen ; Ahituv, Nadav. / Limb development : A paradigm of gene regulation. In: Nature Reviews Genetics. 2017 ; Vol. 18, No. 4. pp. 245-258.
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