Light scattering of human red blood cells during metabolic remodeling of the membrane

Yongkeun Park, Catherine A. Best-Popescu, Ramachandra R. Dasari, Gabriel Popescu

Research output: Contribution to journalArticlepeer-review

Abstract

We present the light scattering properties of individual human red blood cells (RBCs). We show that both the RBC static and dynamic scattering signals are altered by adenosine 5'-triphosphate (ATP)-driven membrane metabolic remodeling. To measure the light scattering signal from individual RBCs, we use diffraction phase microscopy together with a Fourier transform light scattering technique. RBC cytosolic ATPs are both chemically and metabolically depleted, and the corresponding scattering signals are compared with the light scattering signal of normal RBCs having physiologic levels of ATP.

Original languageEnglish (US)
Article number011013
JournalJournal of biomedical optics
Volume16
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • erythrocyte
  • light scattering
  • quantitative phase microscopy
  • red blood cells

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

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