Light-responsive helical polypeptides capable of reducing toxicity and unpacking DNA: Toward nonviral gene delivery

Lichen Yin; Haoyu Tang; Kyung Hoon Kim; Nan Zheng; Ziyuan Song; Nathan P. Gabrielson; Hua Lu; Jianjun Cheng

doi:10.1002/anie.201302820

Light-responsive helical polypeptides capable of reducing toxicity and unpacking DNA: Toward nonviral gene delivery

Lichen Yin, Haoyu Tang, Kyung Hoon Kim, Nan Zheng, Ziyuan Song, Nathan P. Gabrielson, Hua Lu, Jianjun Cheng

Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Gene delivery vehicles: Helical, cationic polypeptides with light-responsive domains showed potent membrane activity and promoted efficient cellular internalization of DNA (see picture). After transfection, a light trigger induces protecting-group removal to expose anionic carboxylate groups. The reduced cationic charge and helix distortion of the polypeptides result in enhanced DNA unpacking and reduced material toxicity because of the eliminated membrane activity.

Original language	English (US)
Pages (from-to)	9182-9186
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	35
DOIs	https://doi.org/10.1002/anie.201302820
State	Published - Aug 26 2013

Keywords

cell-penetrating peptides
charge conversion
helical structures
nonviral gene delivery

ASJC Scopus subject areas

General Chemistry
Catalysis

Online availability

10.1002/anie.201302820

Library availability

Discover UIUC Full Text

Cite this

@article{592bac6d4d0a403dafe5edb2ba10953e,

title = "Light-responsive helical polypeptides capable of reducing toxicity and unpacking DNA: Toward nonviral gene delivery",

abstract = "Gene delivery vehicles: Helical, cationic polypeptides with light-responsive domains showed potent membrane activity and promoted efficient cellular internalization of DNA (see picture). After transfection, a light trigger induces protecting-group removal to expose anionic carboxylate groups. The reduced cationic charge and helix distortion of the polypeptides result in enhanced DNA unpacking and reduced material toxicity because of the eliminated membrane activity.",

keywords = "cell-penetrating peptides, charge conversion, helical structures, nonviral gene delivery",

author = "Lichen Yin and Haoyu Tang and Kim, {Kyung Hoon} and Nan Zheng and Ziyuan Song and Gabrielson, {Nathan P.} and Hua Lu and Jianjun Cheng",

year = "2013",

month = aug,

day = "26",

doi = "10.1002/anie.201302820",

language = "English (US)",

volume = "52",

pages = "9182--9186",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley & Sons, Ltd.",

number = "35",

}

TY - JOUR

T1 - Light-responsive helical polypeptides capable of reducing toxicity and unpacking DNA

T2 - Toward nonviral gene delivery

AU - Yin, Lichen

AU - Tang, Haoyu

AU - Kim, Kyung Hoon

AU - Zheng, Nan

AU - Song, Ziyuan

AU - Gabrielson, Nathan P.

AU - Lu, Hua

AU - Cheng, Jianjun

PY - 2013/8/26

Y1 - 2013/8/26

N2 - Gene delivery vehicles: Helical, cationic polypeptides with light-responsive domains showed potent membrane activity and promoted efficient cellular internalization of DNA (see picture). After transfection, a light trigger induces protecting-group removal to expose anionic carboxylate groups. The reduced cationic charge and helix distortion of the polypeptides result in enhanced DNA unpacking and reduced material toxicity because of the eliminated membrane activity.

AB - Gene delivery vehicles: Helical, cationic polypeptides with light-responsive domains showed potent membrane activity and promoted efficient cellular internalization of DNA (see picture). After transfection, a light trigger induces protecting-group removal to expose anionic carboxylate groups. The reduced cationic charge and helix distortion of the polypeptides result in enhanced DNA unpacking and reduced material toxicity because of the eliminated membrane activity.

KW - cell-penetrating peptides

KW - charge conversion

KW - helical structures

KW - nonviral gene delivery

UR - http://www.scopus.com/inward/record.url?scp=84883037247&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883037247&partnerID=8YFLogxK

U2 - 10.1002/anie.201302820

DO - 10.1002/anie.201302820

M3 - Article

C2 - 23832670

AN - SCOPUS:84883037247

SN - 1433-7851

VL - 52

SP - 9182

EP - 9186

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 35

ER -

Light-responsive helical polypeptides capable of reducing toxicity and unpacking DNA: Toward nonviral gene delivery

Abstract

Keywords

ASJC Scopus subject areas

Online availability

Library availability

Related links

Fingerprint

Cite this