Ligand-receptor binding on nanoparticle-stabilized liposome surfaces

Liangfang Zhang, Kevin Dammann, Sung Chul Bae, Steve Granick

Research output: Contribution to journalArticlepeer-review


We explore the access of receptor (streptavidin) to liposome-immobilized ligand (biotin) in cases where the liposomes are stabilized against fusion by allowing nanoparticles to adsorb. It is found that receptor binding persists over that range of nanoparticle surface coverage where liposome fusion and large-scale aggregation are prevented. This indicates that liposome outer surfaces, in the presence of stabilizers, remain biofunctionalizable, and may have bearing on explaining the long circulation time of stabilized liposomes as drug delivery vehicles.

Original languageEnglish (US)
Pages (from-to)551-553
Number of pages3
JournalSoft Matter
Issue number5
StatePublished - May 14 2007

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics


Dive into the research topics of 'Ligand-receptor binding on nanoparticle-stabilized liposome surfaces'. Together they form a unique fingerprint.

Cite this