The concept of Lewis base activation of Lewis acids has been applied to the selenolactonization reaction. Through the use of substoichiometric amounts of Lewis bases with "soft" donor atoms (S, Se, P) significant rate enhancements over the background reaction are seen. Preliminary mechanistic investigations have revealed the resting state of the catalyst as well as the significance of a weak Bronsted acid promoter.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Sep 13 2007|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry