Lewis base activation of lewis acids: Development of a lewis base catalyzed selenolactonization

Scott E. Denmark, William R. Collins

Research output: Contribution to journalArticlepeer-review

Abstract

The concept of Lewis base activation of Lewis acids has been applied to the selenolactonization reaction. Through the use of substoichiometric amounts of Lewis bases with "soft" donor atoms (S, Se, P) significant rate enhancements over the background reaction are seen. Preliminary mechanistic investigations have revealed the resting state of the catalyst as well as the significance of a weak Bronsted acid promoter.

Original languageEnglish (US)
Pages (from-to)3801-3804
Number of pages4
JournalOrganic Letters
Volume9
Issue number19
DOIs
StatePublished - Sep 13 2007

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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