Levels of brain lipids in white matter from undernourished Sinclair (S‐1) miniature swine

Grace Y. Sun, M. E. Tumbleson

Research output: Contribution to journalArticlepeer-review


It Has been suggested previously that animal models are the preferred method for biochemical study concerned with protein‐calorie malnutrition (Kirsch, Saunders and Brock, 1968; Dobbing, 1970). That the brain is one of the least vulnerable organs to be affected by dietary deprivation has been reported for swine (Platt, Heard and Stewart, 1964; Tumbleson, Tinsley, Corwin, Flatt and Flynn, 1969; Tumbleson, Tinsley, Mulder and Flait, 1970), rhesus monkeys (Ordy, Samorajski and Hershberger, 1970) and rats (Brown and Guthrie, 1968). However, alteration of brain composition as a result of protein‐calorie malnutrition at a young age may have important effects on the mental and behavioural activities of the maturing subjects (Winick, 1970; Cravioto, 1970). In a previous study on the effect of undernutrition in young miniature swine, it was noted that there was an elevation in the levels of cholesterol and glucose in serum of pigs fed the low protein diet (Tumblesonet al., 1969). The duration of such elevations was usually 2–8 weeks after administration of the test diet. Since cholesterol, as well as other chemical constituents, in serum is important for the biosynthesis of brain membranes, the present study was designed to assess the effect of undernutrition on levels of major brain lipids.

Original languageEnglish (US)
Pages (from-to)909-912
Number of pages4
JournalJournal of Neurochemistry
Issue number3
StatePublished - Mar 1972
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


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