TY - JOUR
T1 - Leukocytes navigate by compass
T2 - Roles of PI3Kγ and its lipid products
AU - Rickert, Paula
AU - Weiner, Orion D.
AU - Wang, Fei
AU - Bourne, Henry R.
AU - Servant, Guy
PY - 2000/11/1
Y1 - 2000/11/1
N2 - Morphologic polarity is necessary for the motility of mammalian cells. In leukocytes responding to a chemoattractant, this polarity is regulated by activities of small Rho guanosine triphosphatases (Rho GTPases) and the phosphoinositide 3-kinases (PI3Ks). Moreover, in neutrophils, lipid products of PI3Ks appear to regulate activation of Rho GTPases, are required for cell motility and accumulate asymmetrically to the plasma membrane at the leading edge of polarized cells. By spatially regulating Rho GTPases and organizing the leading edge of the cell, PI3Ks and their lipid products could play pivotal roles not only in establishing leukocyte polarity but also as compass molecules that tell the cell where to crawl. Copyright (C) 2000 Elsevier Science Ltd.
AB - Morphologic polarity is necessary for the motility of mammalian cells. In leukocytes responding to a chemoattractant, this polarity is regulated by activities of small Rho guanosine triphosphatases (Rho GTPases) and the phosphoinositide 3-kinases (PI3Ks). Moreover, in neutrophils, lipid products of PI3Ks appear to regulate activation of Rho GTPases, are required for cell motility and accumulate asymmetrically to the plasma membrane at the leading edge of polarized cells. By spatially regulating Rho GTPases and organizing the leading edge of the cell, PI3Ks and their lipid products could play pivotal roles not only in establishing leukocyte polarity but also as compass molecules that tell the cell where to crawl. Copyright (C) 2000 Elsevier Science Ltd.
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U2 - 10.1016/S0962-8924(00)01841-9
DO - 10.1016/S0962-8924(00)01841-9
M3 - Review article
C2 - 11050418
AN - SCOPUS:0034332904
SN - 0962-8924
VL - 10
SP - 466
EP - 473
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 11
ER -